Tclin NDUFB11 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to ubiquinone. Mutations in the human gene are associated with linear skin defects with multiple congenital anomalies 3 and mitochondrial complex I deficiency. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q9NX14
• Q5JRR3
• Q5JRR4
• Q6IAB6
• Q8WZ96
• Q9BXX9

Gene Name

• NDUFB11

Ensembl ID

• ENST00000276062
• ENSP00000276062
• ENSG00000147123
• ENST00000377811
• ENSP00000367042

Symbol

• ESSS
• Np15
• P17.3
• NP17.3
• CI-ESSS
• MC1DN30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
cellular component	0.91
histone modification site profile	0.91
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Nadh Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 11, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Nadh Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 11, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.46   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.46   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1