Property Summary

NCBI Gene PubMed Count 56
PubMed Score 134.66
PubTator Score 71.35

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
glioblastoma multiforme 347 1.89487970144846E-24
astrocytoma 1493 7.97001940107499E-23
oligodendroglioma 2849 5.63658705142514E-20
non-small cell lung cancer 2798 2.98701356259424E-10
ovarian cancer 8492 3.67457874421445E-7
chronic lymphosyte leukemia 232 7.61539202724762E-7
psoriasis 6685 1.51855247679605E-6
juvenile dermatomyositis 1189 6.25300633622769E-5
cystic fibrosis 1670 3.16029508247352E-4
tuberculosis and treatment for 3 months 327 3.18415274391646E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 3.2080963811063E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00115270339392088
lung adenocarcinoma 2714 0.00143411332834125
active ulcerative colitis 477 0.00291096522946857
acute quadriplegic myopathy 1157 0.010980651670682
colon cancer 1475 0.0119269116697792
Down syndrome 548 0.0288932831053805
ependymoma 2514 0.0351979253608472
active Crohn's disease 918 0.0381278786437742
Disease Target Count Z-score Confidence
Cancer 2346 3.095 1.5


  Differential Expression (20)


Accession Q9NX09 Q9H0S3
Symbols Dig2




  Ortholog (11)

Gene RIF (43)

26968249 C/EBPbeta promotes autophagy in PC3 cells by augmenting REDD1 expression.
26487002 These data highlight the central role of REDD1 in regulating both protein synthesis and autophagy in skeletal muscle during sepsis.
26269521 Findings from this study propose a REDD1-regulated mechanism in T2D skeletal muscle that may contribute to whole body insulin resistance and may be a target to improve insulin action in insulin-resistant individuals.
25504525 REDD1 knockout (KO) mice, all skin compartments, epidermal stem, and progenitor cells were protected from atrophic effects of glucocorticoids.
25337238 REDD1 and p-AKT over-expression may serve as a prognostic biomarker in ovarian cancer, but KRAS mutations and REDD1 protein over-expression were not correlated in OC.
25255219 MiR-630 reduced apoptosis by downregulating several apoptotic modulators, PARP3, DDIT4, and EP300.
25147182 analysis of ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1
25058423 Caspase 3 cleaved REDD1 during apoptotic activation.
25056877 the results demonstrate that REDD1 acts not only as a repressor of mTORC1 but also as a constant modulator of the phosphorylation of Akt in response to growth factors and nutrients.
24728411 these postmortem and preclinical findings identify REDD1 as a critical mediator of the atrophy of neurons and depressive behavior caused by chronic stress exposure

AA Sequence

STGFRVIKKKLYSSEQLLIEEC                                                    211 - 232

Text Mined References (63)

PMID Year Title
26968249 2016 C/EBP? regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion.
26487002 2015 Disruption of REDD1 gene ameliorates sepsis-induced decrease in mTORC1 signaling but has divergent effects on proteolytic signaling in skeletal muscle.
26269521 2015 Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics.
25504525 2014 REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids.
25337238 2014 REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer.
25255219 2014 MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells.
25147182 2014 Quantitative Lys-?-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.
25130324 2014 A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
25058423 2014 A new posttranslational regulation of REDD1/DDIT4 through cleavage by caspase 3 modifies its cellular function.
25056877 2014 REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.