Property Summary

NCBI Gene PubMed Count 19
Grant Count 14
R01 Count 6
Funding $713,473.59
PubMed Score 153.66
PubTator Score 19.32

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (3)

Expression

  Differential Expression (2)

Disease log2 FC p
glioblastoma 1.100 0.000
medulloblastoma, large-cell 1.200 0.000

Gene RIF (5)

PMID Text
23519793 A crystal structure of TXNL4B was determined at 1.33 A resolution and refined to an Rwork of 0.13 and an Rfree of 0.18 with one native dimer in the asymmetric unit.
22082156 Knockdown of thioredoxin-like 4B (TXNL4B) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N
16511018 The human gene coding for the spliceosomal protein thioredoxin-like 4B (TXNL4B) was overexpressed in Escherichia coli and the encoded protein was purified and crystallized.
16142897 crystal structure; in contrast to hDim1, hDim2 forms stable homodimers
15161931 DLP is implicated in not only cell cycle progression but also in a more specific molecular process such as pre-mRNA splicing

AA Sequence

MSFLLPKLTSKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDILSKTSSDLSKMAAIYLVDVDQTAVYT      1 - 70
QYFDISYIPSTVFFFNGQHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGAMRGKLIVQSPIDPKNIP     71 - 140
KYDLLYQDI                                                                 141 - 149
//

Text Mined References (20)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24097068 2013 Discovery and refinement of loci associated with lipid levels.
23519793 2013 High-resolution crystal structure of human Dim2/TXNL4B.
22916037 2012 Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
22403646 2012 A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.
20686565 2010 Biological, clinical and population relevance of 95 loci for blood lipids.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16511018 2005 Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
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