Property Summary

NCBI Gene PubMed Count 16
PubMed Score 3.69
PubTator Score 2.20

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (5)

Disease log2 FC p
osteosarcoma -1.159 0.000
atypical teratoid/rhabdoid tumor 1.200 0.000
medulloblastoma, large-cell 1.600 0.000
sonic hedgehog group medulloblastoma 1.400 0.000
ovarian cancer -1.300 0.000

Synonym

Accession Q9NWX6 D3DQJ5 Q53G12 Q7L5R3 Q9H0S2
Symbols ICF45
IHG-1
hTHG1

Gene

PDB

3OTB   3OTC   3OTD   3OTE  

Gene RIF (7)

PMID Text
25008184 IHG-1 is a novel regulator of both mitochondrial dynamics and bioenergetic function and contributes to cell survival following oxidant stress. Increased IHG-1 expression may contribute to pathogenesis of diabetic kidney disease.
22136300 The high-resolution crystal structure of human Thg1 reveals remarkable structural similarity between canonical DNA/RNA polymerases and eukaryotic Thg1.
21784897 IHG-1 increases mitochondrial biogenesis by promoting PGC-1alpha-dependent processes, potentially contributing to the pathogenesis of renal fibrosis
21078997 The catalytic domain of Thg1 shares both a common architecture and a two-metal ion-dependent mechanism with canonical 5'-3' DNA polymerases.
20877624 Observational study of gene-disease association. (HuGE Navigator)
18508967 induced in high glucose-1 (IHG-1)which increases in diabetic nephropathy, may enhance the actions of TGF-beta1 and contribute to the development of tubulointerstitial fibrosis
15459185 ICF45 is a highly conserved novel protein, which is expressed in a cell cycle-dependent manner and seemed to be involved in cell cycle progression and cell proliferation

AA Sequence

MWGACKVKVHDSLATISITLRRYLRLGATMAKSKFEYVRDFEADDTCLAHCWVVVRLDGRNFHRFAEKHN      1 - 70
FAKPNDSRALQLMTKCAQTVMEELEDIVIAYGQSDEYSFVFKRKTNWFKRRASKFMTHVASQFASSYVFY     71 - 140
WRDYFEDQPLLYPPGFDGRVVVYPSNQTLKDYLSWRQADCHINNLYNTVFWALIQQSGLTPVQAQGRLQG    141 - 210
TLAADKNEILFSEFNINYNNELPMYRKGTVLIWQKVDEVMTKEIKLPTEMEGKKMAVTRTRTKPVPLHCD    211 - 280
IIGDAFWKEHPEILDEDS                                                        281 - 298
//

Publication (17)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25008184 2014 IHG-1 increases mitochondrial fusion and bioenergetic function.
23844012 2013 Structural studies of a bacterial tRNA(HIS) guanylyltransferase (Thg1)-like protein, with nucleotide in the activation and nucleotidyl transfer sites.
22136300 2012 Kinetic analysis of 3'-5' nucleotide addition catalyzed by eukaryotic tRNA(His) guanylyltransferase.
21784897 2011 IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1?.
21078997 2010 Crystal structure of a reverse polymerase.
21059936 2010 tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases.
21044950 2011 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
18508967 2008 IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis.
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