Tbio OXSM 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

Protein Summary

Description

May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• Q9NWU1

Gene Name

• OXSM

Ensembl ID

• ENST00000280701
• ENSP00000280701
• ENSG00000151093
• ENST00000420173
• ENSP00000411303

Symbol

• KS
• CEM1
• KASI
• FASN2D

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
kinase perturbation	0.88
protein domain	0.85
disease perturbation	0.79
histone modification site profile	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.37   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.37   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0