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Tbio
PAK1IP1
p21-activated protein kinase-interacting protein 1

Protein Summary
Description
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379568
  • ENSP00000368887
  • ENSG00000111845
  • ENST00000644756
  • ENSP00000496482
  • ENSG00000285226

Symbol
  • PIP1
  • WDR84
  • PIP1
  • MAK11
  • WDR84
  • hPIP1
  • bA421M1.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.9
transcription factor binding site profile
0.88
disease perturbation
0.87
PubMedID
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0