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Tdark Protein SDA1 homolog

Required for 60S pre-ribosomal subunits export to the cytoplasm.

 Comments

Property Summary

NCBI Gene PubMed Count 13
PubMed Score 0.87
PubTator Score 0.83

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
juvenile dermatomyositis 1189 5.29410481207399E-10
ovarian cancer 8492 2.55066535774851E-6
osteosarcoma 7933 6.48610085341623E-6
ulcerative colitis 2087 2.1845175612389E-5
psoriasis 6685 4.12807469107331E-5
Pick disease 1893 8.89849413813855E-5
atypical teratoid / rhabdoid tumor 4369 2.41573399802839E-4
medulloblastoma, large-cell 6234 0.00183162492140959
adult high grade glioma 2148 0.00737278000662006
glioblastoma 5572 0.0115561462797003
colon cancer 1475 0.014777859418425
Gaucher disease type 1 171 0.0180550680805242
Breast cancer 3099 0.0265767840127148

Expression

  Differential Expression (13)

Disease log2 FC p
psoriasis -2.500 0.000
osteosarcoma 1.493 0.000
atypical teratoid / rhabdoid tumor -1.600 0.000
glioblastoma -1.200 0.012
medulloblastoma, large-cell -1.300 0.002
juvenile dermatomyositis 1.255 0.000
colon cancer 1.600 0.015
Breast cancer 2.400 0.027
adult high grade glioma -1.200 0.007
Pick disease -1.100 0.000
ulcerative colitis 1.100 0.000
ovarian cancer 2.000 0.000
Gaucher disease type 1 1.100 0.018

Synonym

Accession Q9NVU7 Q32Q11 Q68D52 Q7Z5U4 Q9H831 Q9H9P6
Symbols

Gene

SDAD1

  Ortholog (15)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
Fruitfly OMA Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

 GO Component (2)

 GO Process (4)

 Compartment GO Term (21)

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 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (1)

 UniProt Keyword (10)

Gene RIF (3)

PMID Text
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
15607425 PUM2 and DAZL, are capable of binding the same mRNA sequences in the 3'UTR of human SDAD1 mRNA.
14976432 hSDA is the human ortholog of the yeast SDA1 gene

AA Sequence 

MSNRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCY      1 - 70
PEYLSNFPQEVKDLLSCNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELFRCHDKLLRKTLYTH     71 - 140
IVTDIKNINAKHKNNKVNVVLQNFMYTMLRDSNATAAKMSLDVMIELYRRNIWNDAKTVNVITTACFSKV    141 - 210
TKILVAALTFFLGKDEDEKQDSDSESEDDGPTARDLLVQYATGKKSSKNKKKLEKAMKVLKKQKKKKKPE    211 - 280
VFNFSAIHLIHDPQDFAEKLLKQLECCKERFEVKMMLMNLISRLVGIHELFLFNFYPFLQRFLQPHQREV    281 - 350
TKILLFAAQASHHLVPPEIIQSLLMTVANNFVTDKNSGEVMTVGINAIKEITARCPLAMTEELLQDLAQY    351 - 420
KTHKDKNVMMSARTLIHLFRTLNPQMLQKKFRGKPTEASIEARVQEYGELDAKDYIPGAEVLEVEKEENA    421 - 490
ENDEDGWESTSLSEEEDADGEWIDVQHSSDEEQQEISKKLNSMPMEERKAKAAAISTSRVLTQEDFQKIR    491 - 560
MAQMRKELDAAPGKSQKRKYIEIDSDEEPRGELLSLRDIERLHKKPKSDKETRLATAMAGKTDRKEFVRK    561 - 630
KTKTNPFSSSTNKEKKKQKNFMMMRYSQNVRSKNKRSFREKQLALRDALLKKRKRMK                 631 - 687
//

Text Mined References (27)

PMID Year Title
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
20834067 2010 Joint influence of small-effect genetic variants on human longevity.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
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