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Tdark Protein SDA1 homolog

Required for 60S pre-ribosomal subunits export to the cytoplasm.

 Comments

Property Summary

NCBI Gene PubMed Count 13
PubMed Score 0.87
PubTator Score 0.83

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (13)

Disease Z-score Confidence
Breast cancer 3,094
Gaucher disease type 1 171
Pick disease 1,893
adult high grade glioma 2,148
atypical teratoid / rhabdoid tumor 4,369
colon cancer 1,475
glioblastoma 5,572
juvenile dermatomyositis 1,189
medulloblastoma, large-cell 6,234
osteosarcoma 7,933
ovarian cancer 8,484
psoriasis 6,685
ulcerative colitis 2,087

Expression

  Differential Expression (13)

Disease log2 FC p
psoriasis -2.500 0.000
osteosarcoma 1.493 0.000
atypical teratoid / rhabdoid tumor -1.600 0.000
glioblastoma -1.200 0.012
medulloblastoma, large-cell -1.300 0.002
juvenile dermatomyositis 1.255 0.000
colon cancer 1.600 0.015
Breast cancer 2.400 0.027
adult high grade glioma -1.200 0.007
Pick disease -1.100 0.000
ulcerative colitis 1.100 0.000
ovarian cancer 2.000 0.000
Gaucher disease type 1 1.100 0.018

Synonym

Accession Q9NVU7 Q32Q11 Q68D52 Q7Z5U4 Q9H831 Q9H9P6
Symbols

Gene

SDAD1

 GO Component (2)

 GO Process (4)

 Compartment GO Term (20)

See all...

 GWAS Trait (1)

Pathway (1)

 UniProt Keyword (10)

Gene RIF (3)

PMID Text
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
15607425 PUM2 and DAZL, are capable of binding the same mRNA sequences in the 3'UTR of human SDAD1 mRNA.
14976432 hSDA is the human ortholog of the yeast SDA1 gene

AA Sequence 

MSNRNNNKLPSNLPQLQNLIKRDPPAYIEEFLQQYNHYKSNVEIFKLQPNKPSKELAELVMFMAQISHCY      1 - 70
PEYLSNFPQEVKDLLSCNHTVLDPDLRMTFCKALILLRNKNLINPSSLLELFFELFRCHDKLLRKTLYTH     71 - 140
IVTDIKNINAKHKNNKVNVVLQNFMYTMLRDSNATAAKMSLDVMIELYRRNIWNDAKTVNVITTACFSKV    141 - 210
TKILVAALTFFLGKDEDEKQDSDSESEDDGPTARDLLVQYATGKKSSKNKKKLEKAMKVLKKQKKKKKPE    211 - 280
VFNFSAIHLIHDPQDFAEKLLKQLECCKERFEVKMMLMNLISRLVGIHELFLFNFYPFLQRFLQPHQREV    281 - 350
TKILLFAAQASHHLVPPEIIQSLLMTVANNFVTDKNSGEVMTVGINAIKEITARCPLAMTEELLQDLAQY    351 - 420
KTHKDKNVMMSARTLIHLFRTLNPQMLQKKFRGKPTEASIEARVQEYGELDAKDYIPGAEVLEVEKEENA    421 - 490
ENDEDGWESTSLSEEEDADGEWIDVQHSSDEEQQEISKKLNSMPMEERKAKAAAISTSRVLTQEDFQKIR    491 - 560
MAQMRKELDAAPGKSQKRKYIEIDSDEEPRGELLSLRDIERLHKKPKSDKETRLATAMAGKTDRKEFVRK    561 - 630
KTKTNPFSSSTNKEKKKQKNFMMMRYSQNVRSKNKRSFREKQLALRDALLKKRKRMK                 631 - 687
//

Text Mined References (27)

PMID Year Title
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
20834067 2010 Joint influence of small-effect genetic variants on human longevity.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
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