Tbio TMLHE Trimethyllysine dioxygenase, mitochondrial

Protein Summary

Description

Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (PubMed:11431483, PubMed:23092983). This gene encodes the protein trimethyllysine dioxygenase which is the first enzyme in the carnitine biosynthesis pathway. Carnitine play an essential role in the transport of activated fatty acids across the inner mitochondrial membrane. The encoded protein converts trimethyllysine into hydroxytrimethyllysine. A pseudogene of this gene is found on chromosome X. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q9NVH6
• A8K6M9
• B4E3R3
• Q5TZB5
• Q6IA90
• Q8TBT0

Gene Name

• TMLHE

Ensembl ID

• ENST00000334398
• ENSP00000335261
• ENSG00000185973
• ENST00000369439
• ENSP00000358447

Symbol

• TMLH
• TMLD
• TMLH
• BBOX2
• AUTSX6
• TMLHED
• XAP130

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
molecular function	0.79
tissue sample	0.69
interacting protein	0.63
microRNA	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.44   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 190   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.44   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0