Tbio DnaJ homolog subfamily C member 11

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Isoform 1: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.

Comments

Property Summary

NCBI Gene PubMed Count	16
PubMed Score	2.83

PubTator Score	1.28

Knowledge Summary

Patent

No data available

TINX Plot

Disease	Target Count	P-value
psoriasis	6694	7.8e-04

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.9

Expression

Specificity
Differential

Differential Expression (1)

Disease	log2 FC	p
psoriasis	1.200	7.8e-04

Spleen 17,614

Cells - Transformed fibroblasts 17,577

Cells - EBV-transformed lymphocytes 18,186

Ovary 17,971

Brain - Cerebellum 17,983

Brain - Cerebellar Hemisphere 18,015

Uterus 17,618

Nerve - Tibial 18,007

Small Intestine - Terminal Ileum 17,954

Testis 18,518

Skin - Sun Exposed (Lower leg) 17,968

Thyroid 18,024

Adrenal Gland 18,071

Vagina 17,834

Skin - Not Sun Exposed (Suprapubic) 18,081

Colon - Transverse 17,825

Breast - Mammary Tissue 18,103

Adipose - Subcutaneous 18,110

Artery - Tibial 17,631

Brain - Cortex 18,039

Esophagus - Mucosa 18,076

Colon - Sigmoid 18,089

Esophagus - Muscularis 18,017

Muscle - Skeletal 17,778

Prostate 18,213

Brain - Frontal Cortex (BA9) 18,069

Artery - Coronary 17,949

Pituitary 18,147

Minor Salivary Gland 18,005

Adipose - Visceral (Omentum) 17,937

Esophagus - Gastroesophageal Junction 18,000

Artery - Aorta 17,896

Stomach 17,879

Heart - Atrial Appendage 17,896

Kidney - Cortex 17,329

Lung 18,057

Brain - Nucleus accumbens (basal ganglia... 18,024

Brain - Anterior cingulate cortex (BA24) 17,989

Brain - Spinal cord (cervical c-1) 17,973

Brain - Hypothalamus 18,169

Brain - Caudate (basal ganglia) 18,001

Brain - Hippocampus 18,011

Brain - Amygdala 18,006

Brain - Substantia nigra 17,981

Brain - Putamen (basal ganglia) 17,863

Liver 18,071

Pancreas 18,123

Heart - Left Ventricle 18,006

Whole Blood 17,439

Adult Retina 10,115

Adult Frontal Cortex 9,048

Adult Kidney 6,723

Fetal Ovary 9,118

Adult Pancreas 9,168

Adult Testis 10,836

Fetal Heart 9,228

Adult Heart 6,506

Adult Ovary 10,192

Adult Liver 9,113

Adult Colon 7,915

Adult Urinary Bladder 7,592

CD4 Cells 7,773

Adult Spinal Cord 7,594

Monocytes 7,422

Adult Rectum 8,022

Adult Adrenal 8,475

CD8 Cells 9,840

Adult Gallbladder 7,612

Fetal Gut 8,640

Fetal Brain 7,866

Adult Lung 6,663

Fetal Testis 7,955

Adult Prostate 8,952

Fetal Liver 8,402

B Cells 9,086

Adult Esophagus 4,936

Platelets 6,131

NK Cells 8,475

Adrenal gland

Blood platelet

Brain

Colon

Frontal lobe

Gall bladder

Gut

Heart

Kidney

Liver

Lung

B-lymphocyte

Monocyte

Natural killer cell

Esophagus

Ovary

Pancreas

Placenta 6,083

Prostate gland

Rectum

Retina

Spinal cord

Testis

Urinary bladder

BTO:0004410

BTO:0005453

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

cervix, uterine 15,871

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

esophagus 15,898

fallopian tube 16,245

gallbladder 16,333

heart muscle 14,972

kidney 15,917

liver 14,587

lung 16,312

lymph node 15,833

ovary 15,408

pancreas 14,070

parathyroid gland 14,769

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

seminal vesicle 15,918

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

tonsil 15,400

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cardiovascular System 15,192

Brain 7,346

Breast cancer cell 221

Teratocarcinoma cell 604

Lung 2,286

Placenta 3,079

See source...

Synonym

Accession	Q9NVH1 Q4VWF5 Q5VZN0 Q6PK20 Q6PK70 Q8NDM2 Q96CL7
Symbols	dJ126A5.1

Gene

DNAJC11

Ortholog (13)

Species	Source	Disease
Xenopus 10,463	Inparanoid OMA EggNOG
C. elegans 3,178	Inparanoid OMA EggNOG
Fruitfly 3,048	Inparanoid EggNOG
Chimp 14,136	OMA EggNOG
Macaque 12,758	Inparanoid OMA EggNOG
Mouse 16,567	Inparanoid OMA EggNOG
Rat 15,112	Inparanoid OMA EggNOG
Dog 15,069	Inparanoid OMA EggNOG
Horse 14,249	Inparanoid OMA EggNOG
Cow 15,316	Inparanoid OMA EggNOG
Pig 10,164	OMA EggNOG
Opossum 12,223	Inparanoid OMA EggNOG
Chicken 7,823	Inparanoid OMA EggNOG

UniProt Keyword (11)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Alternative splicing 10,528

Phosphoprotein 8,216

Membrane 7,361

Acetylation 3,409

Coiled coil 2,153

Mitochondrion 1,147

Mitochondrion outer membrane 124

See all...

GO Component (4)

mitochondrial inner membrane 432

mitochondrial outer membrane 163

extracellular exosome 2,767

mitochondrion 1,281

GO Process (1)

cristae formation 31

Compartment GO Term (36)

Bounding membrane of organelle 1,956

Cell 16,178

Cell part 16,177

Cytoplasm 10,983

Cytoplasmic part 9,247

Cytosol 6,686

GO:0031975 1,150

Integral component of mitochondrial inne... 37

Integral component of mitochondrial memb... 65

Integral component of organelle membrane 150

Intracellular 14,108

Intracellular membrane-bounded organelle 10,341

Intracellular organelle 12,025

Intracellular organelle part 8,784

Intracellular part 13,972

See all...

MGI Phenotype (9)

endocrine-exocrine gland phenotype 2,293

growth-size-body region phenotype 4,157

cellular phenotype 3,637

nervous system phenotype 3,447

hematopoietic system phenotype 3,383

mortality-aging 5,018

immune system phenotype 3,461

behavior-neurological phenotype 3,401

muscle phenotype 1,479

GWAS Trait (1)

Schizophrenia 533

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Pathway (3)

Organelle biogenesis and maintenance 261

Mitochondrial biogenesis 74

Cristae formation 14

Protein-protein Interaction (6)

WDR73 TAX1BP1 PDE6D ZNHIT2 YTHDF1 RNF214

Gene RIF (6)

AA Sequence

MATALSEEELDNEDYYSLLNVRREASSEELKAAYRRLCMLYHPDKHRDPELKSQAERLFNLVHQAYEVLS      1 - 70
DPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEFERLQREREERRLQQRTNPKGTISVGVDATDLFD     71 - 140
RYDEEYEDVSGSSFPQIEINKMHISQSIEAPLTATDTAILSGSLSTQNGNGGGSINFALRRVTSAKGWGE    141 - 210
LEFGAGDLQGPLFGLKLFRNLTPRCFVTTNCALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGIQSAM    211 - 280
NTSIVRDTKTSHFTVALQLGIPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTVVEYGAERKISRHSVLG    281 - 350
AAVSVGVPQGVSLKVKLNRASQTYFFPIHLTDQLLPSAMFYATVGPLVVYFAMHRLIIKPYLRAQKEKEL    351 - 420
EKQRESAATDVLQKKQEAESAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVNDKSRKSEKVKVIDVTV    421 - 490
PLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMVLDSEALRIPKQSHRIDTDG     491 - 559
//

Text Mined References (20)

Summary
Details

	PMID	Year	Title

Tbio DnaJ homolog subfamily C member 11 Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent

No data available

TINX Plot

Disease (2)

Expression

Differential Expression (1)

Synonym

Gene

Ortholog (13)

UniProt Keyword (11)

GO Component (4)

GO Process (1)

Compartment GO Term (36)

MGI Phenotype (9)

GWAS Trait (1)

HCA RNA Cell Line (56)

Pathway (3)

Protein-protein Interaction (6)

Gene RIF (6)

AA Sequence

Text Mined References (20)

Tbio DnaJ homolog subfamily C member 11

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