Tchem TDP1 Tyrosyl-DNA phosphodiesterase 1

Protein Summary

Description

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q9NUW8
• Q2HXX4
• Q86TV8
• Q96BK7
• Q9NZM7
• Q9NZM8
• Tyr-DNA phosphodiesterase 1

Gene Name

• TDP1

Ensembl ID

• ENST00000335725
• ENSP00000337353
• ENSG00000042088
• ENST00000393454
• ENSP00000377099

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
kinase perturbation	0.81
transcription factor binding site profile	0.69
molecular function	0.67
tissue	0.64

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphodiesterase / Tyrosyl-dna Phosphodiesterase 1

DTO Classes

Protein / Enzyme / Hydrolase / Phosphodiesterase / Tyrosyl-dna Phosphodiesterase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.52   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 309   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.52   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0