| Tbio | Transmembrane protein 106B |
Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Frontotemporal Lobar Degeneration | 6 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 1.4e-07 |
| posterior fossa group A ependymoma | 468 | 2.8e-06 |
| pediatric high grade glioma | 1064 | 8.0e-05 |
| glioblastoma | 5792 | 9.9e-05 |
| osteosarcoma | 7950 | 2.0e-04 |
| cystic fibrosis | 1696 | 4.7e-04 |
| Astrocytoma, Pilocytic | 3081 | 6.9e-04 |
| ovarian cancer | 8520 | 1.3e-03 |
| Multiple myeloma | 1332 | 1.8e-03 |
| Pick disease | 1894 | 1.9e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 5.0e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.8e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.2e-02 |
| acute quadriplegic myopathy | 1158 | 1.8e-02 |
| non primary Sjogren syndrome sicca | 891 | 2.1e-02 |
| spina bifida | 1074 | 4.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Amyotrophic lateral sclerosis | 451 | 3.328 | 0.00299169184048691 |
| Neurodegenerative disease | 414 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Frontotemporal dementia | 51 | 5.91 | 3.0 |
| Hypomyelinating leukodystrophy | 9 | 3.012 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| Amyotrophic lateral sclerosis | 1.011 | 3.0e-03 |
| acute quadriplegic myopathy | 1.071 | 1.8e-02 |
| Astrocytoma, Pilocytic | 1.200 | 6.9e-04 |
| cystic fibrosis | 1.497 | 4.7e-04 |
| glioblastoma | 1.100 | 9.9e-05 |
| intraductal papillary-mucinous adenoma (... | 1.400 | 5.0e-03 |
| intraductal papillary-mucinous carcinoma... | 1.400 | 1.2e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.500 | 7.8e-03 |
| lung adenocarcinoma | 1.200 | 1.4e-07 |
| Multiple myeloma | 1.496 | 1.8e-03 |
| non primary Sjogren syndrome sicca | -1.100 | 2.1e-02 |
| osteosarcoma | 1.891 | 2.0e-04 |
| ovarian cancer | -1.300 | 1.3e-03 |
| pediatric high grade glioma | 1.500 | 8.0e-05 |
| Pick disease | 1.200 | 1.9e-03 |
| posterior fossa group A ependymoma | 1.200 | 2.8e-06 |
| spina bifida | -2.168 | 4.5e-02 |
MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRI 1 - 70 PRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKR 71 - 140 TIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYM 141 - 210 YDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ 211 - 274 //
