| Tbio | Peroxisomal 2,4-dienoyl-CoA reductase |
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Comments
Property Summary
| NCBI Gene PubMed Count | 12 |
| Grant Count | 41 |
| R01 Count | 5 |
| Funding | $29,601,959 |
| PubMed Score | 21.92 |
| PubTator Score | 4.20 |
| Disease | Z-score | Confidence |
|---|---|---|
| Excessive tearing 5 | 3.868 | 1.9 |
| Dacryocystitis 7 | 3.855 | 1.9 |
| Zellweger Syndrome 38 | 3.266 | 1.6 |
| lung adenocarcinoma 2,713 | ||
| ovarian cancer 8,484 | ||
| psoriasis 6,685 |
| Disease | log2 FC | p |
|---|---|---|
| psoriasis | 1.900 | 0.000 |
| lung adenocarcinoma | 1.600 | 0.000 |
| ovarian cancer | -1.300 | 0.000 |
MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAAR 1 - 70 KLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSG 71 - 140 TFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLAPGP 141 - 210 ISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVK 211 - 280 GLPDFASFSAKL 281 - 292 //
| PMID | Year | Title |
|---|---|---|
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
| 22745130 | 2012 | Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal ?-oxidation of unsaturated fatty acids. |
| 20178365 | 2010 | A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. |
| 19608861 | 2009 | Lysine acetylation targets protein complexes and co-regulates major cellular functions. |
| 19027726 | 2009 | The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. |
| 17207965 | 2007 | hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. |
| 17081983 | 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |
| 15616553 | 2004 | The sequence and analysis of duplication-rich human chromosome 16. |
| More... |
