| Tbio | Peroxisomal 2,4-dienoyl-CoA reductase |
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 5.3e-11 |
| ovarian cancer | 8520 | 7.4e-08 |
| psoriasis | 6694 | 5.5e-05 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Excessive tearing | 12 | 3.787 | 1.9 |
| Dacryocystitis | 11 | 3.758 | 1.9 |
| Zellweger syndrome | 37 | 3.2 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| lung adenocarcinoma | 1.600 | 5.3e-11 |
| ovarian cancer | -1.300 | 7.4e-08 |
| psoriasis | 1.900 | 5.5e-05 |
MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAAR 1 - 70 KLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSG 71 - 140 TFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLAPGP 141 - 210 ISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVK 211 - 280 GLPDFASFSAKL 281 - 292 //
