Tbio SMC4 Structural maintenance of chromosomes protein 4

Protein Summary

Description

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016]

Uniprot Accession IDs

• Q9NTJ3
• A6NLT9
• D3DNL8
• O95752
• Q8NDL4
• Q9UNT9
• SMC protein 4

Gene Name

• SMC4

Ensembl ID

• ENST00000344722
• ENSP00000341382
• ENSG00000113810
• ENST00000357388
• ENSP00000349961
• ENST00000462787
• ENSP00000420734

Symbol

• CAPC
• SMC4L1
• CAPC
• CAP-C
• SMC-4
• SMC4L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
co-expressed gene	0.93
protein complex	0.89
disease perturbation	0.87
hub protein	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.58   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.58   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0