Tbio PDS5B Sister chromatid cohesion protein PDS5 homolog B

Protein Summary

Description

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q9NTI5
• Q5R3S3
• Q5W0K8
• Q6NSC3
• Q8IXT6
• Q9H5N8
• Q9Y2I5
• Q9Y451

Gene Name

• PDS5B

Ensembl ID

• ENST00000315596
• ENSP00000313851
• ENSG00000083642
• ENST00000450460
• ENSP00000401619

Symbol

• APRIN
• AS3
• KIAA0979
• AS3
• APRIN
• CG008

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
transcription factor perturbation	0.94
disease perturbation	0.9
kinase perturbation	0.88
drug perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Sister Chromatid Cohesion Protein Pds5 Homolog B

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Sister Chromatid Cohesion Protein Pds5 Homolog B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.57   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.57   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0