| Tbio | Cytokine-inducible SH2-containing protein |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Bacteremia | 3 | 0.0 | 0.0 |
| Dermatitis, Allergic Contact | 67 | 0.0 | 0.0 |
| MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO | 11 | 0.0 | 0.0 |
| Malaria | 160 | 0.0 | 0.0 |
| Precancerous Conditions | 80 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) | 11 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 5.2e-11 |
| pituitary cancer | 1972 | 1.0e-07 |
| adult high grade glioma | 3801 | 5.4e-06 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.9e-04 |
| hepatocellular carcinoma | 547 | 4.1e-03 |
| breast carcinoma | 1638 | 6.3e-03 |
| lung cancer | 4740 | 8.3e-03 |
| osteosarcoma | 7950 | 1.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.300 | 5.4e-06 |
| breast carcinoma | 1.700 | 6.3e-03 |
| hepatocellular carcinoma | 1.200 | 4.1e-03 |
| lung cancer | -1.400 | 8.3e-03 |
| non-small cell lung cancer | -1.061 | 5.2e-11 |
| osteosarcoma | -1.039 | 1.2e-02 |
| pancreatic ductal adenocarcinoma liver m... | -1.740 | 2.9e-04 |
| pituitary cancer | -1.600 | 1.0e-07 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
MVLCVQGPRPLLAVERTGQRPLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCI 1 - 70 AKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRL 71 - 140 DSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKL 141 - 210 VQPFVRRSSARSLQHLCRLVINRLVADVDCLPLPRRMADYLRQYPFQL 211 - 258 //
