| Tbio | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 |
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count |
|---|---|
| Nonorganic psychosis | 84 |
| Psychotic Disorders | 151 |
| Schizophrenia | 1160 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 5.8e-22 |
| lung adenocarcinoma | 2716 | 7.9e-11 |
| non-small cell lung carcinoma | 317 | 9.6e-11 |
| nasopharyngeal carcinoma | 1058 | 2.6e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.8e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 8.3e-05 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.6e-04 |
| pancreatic cancer | 2398 | 4.1e-04 |
| ovarian cancer | 8520 | 6.3e-04 |
| medulloblastoma, large-cell | 6241 | 2.6e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.2e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Newcastle disease | 14 | 3.246 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.200 | 4.8e-05 |
| intraductal papillary-mucinous adenoma (... | 4.600 | 8.3e-05 |
| intraductal papillary-mucinous carcinoma... | 4.800 | 1.6e-04 |
| intraductal papillary-mucinous neoplasm ... | 4.300 | 3.2e-03 |
| lung adenocarcinoma | 1.400 | 7.9e-11 |
| medulloblastoma, large-cell | -1.400 | 2.6e-03 |
| nasopharyngeal carcinoma | -2.600 | 2.6e-05 |
| non-small cell lung carcinoma | 1.200 | 9.6e-11 |
| ovarian cancer | 2.400 | 6.3e-04 |
| pancreatic cancer | 2.500 | 4.1e-04 |
| psoriasis | 1.100 | 5.8e-22 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MRSCLWRCRHLSQGVQWSLLLAVLVFFLFALPSFIKEPQTKPSRHQRTENIKERSLQSLAKPKSQAPTRA 1 - 70 RRTTIYAEPVPENNALNTQTQPKAHTTGDRGKEANQAPPEEQDKVPHTAQRAAWKSPEKEKTMVNTLSPR 71 - 140 GQDAGMASGRTEAQSWKSQDTKTTQGNGGQTRKLTASRTVSEKHQGKAATTAKTLIPKSQHRMLAPTGAV 141 - 210 STRTRQKGVTTAVIPPKEKKPQATPPPAPFQSPTTQRNQRLKAANFKSEPRWDFEEKYSFEIGGLQTTCP 211 - 280 DSVKIKASKSLWLQKLFLPNLTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQL 281 - 350 LLASLPAGSLRCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQ 351 - 420 SLLILGNRGFKNVPLGKDVRYLHFLEGTRDYEWLEALLMNQTVMSKNLFWFRHRPQEAFREALHMDRYLL 421 - 490 LHPDFLRYMKNRFLRSKTLDGAHWRIYRPTTGALLLLTALQLCDQVSAYGFITEGHERFSDHYYDTSWKR 491 - 560 LIFYINHDFKLEREVWKRLHDEGIIRLYQRPGPGTAKAKN 561 - 600 //
