Tchem CYSLTR2 Cysteinyl leukotriene receptor 2

Protein Summary

Description

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NS75
• Q9HCQ2
• CysLTR2

Gene Name

• CYSLTR2

Ensembl ID

• ENST00000282018
• ENSP00000282018
• ENSG00000152207
• ENST00000614739
• ENSP00000477930

Symbol

• CYSLT2
• CYSLT2R
• HG57
• CYSLT2
• GPCR21
• HPN321
• CYSLT2R
• KPG_011
• hGPCR21
• PSEC0146

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.67
cell type or tissue	0.63
microRNA	0.61
ligand (chemical)	0.59
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Cysteinyl Leukotriene Receptor 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Leukotriene Receptor / Cysteinyl Leukotriene Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.75   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.75   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2