| Tbio | CREB/ATF bZIP transcription factor |
Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 1.8e-07 |
| Pick disease | 1894 | 9.7e-07 |
| glioblastoma | 5792 | 2.0e-04 |
| medulloblastoma, large-cell | 6241 | 2.3e-04 |
| ovarian cancer | 8520 | 3.5e-04 |
| gastric cancer | 459 | 4.4e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.2e-03 |
| lung cancer | 4740 | 1.3e-03 |
| pediatric high grade glioma | 1064 | 1.5e-03 |
| osteosarcoma | 7950 | 2.0e-03 |
| group 3 medulloblastoma | 4104 | 2.5e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.7e-03 |
| progressive supranuclear palsy | 676 | 2.8e-03 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.500 | 1.2e-03 |
| gastric cancer | 1.200 | 4.4e-04 |
| glioblastoma | -1.800 | 2.0e-04 |
| group 3 medulloblastoma | 1.300 | 2.5e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 2.7e-03 |
| lung adenocarcinoma | 1.514 | 1.8e-07 |
| lung cancer | 1.200 | 1.3e-03 |
| medulloblastoma, large-cell | -1.600 | 2.3e-04 |
| osteosarcoma | 1.649 | 2.0e-03 |
| ovarian cancer | -1.700 | 3.5e-04 |
| pediatric high grade glioma | -1.300 | 1.5e-03 |
| Pick disease | -1.500 | 9.7e-07 |
| progressive supranuclear palsy | -1.400 | 2.8e-03 |
MRHSLTKLLAASGSNSPTRSESPEPAATCSLPSDLTRAAAGEEETAAAGSPGRKQQFGDEGELEAGRGSR 1 - 70 GGVAVRAPSPEEMEEEAIASLPGEETEDMDFLSGLELADLLDPRQPDWHLDPGLSSPGPLSSSGGGSDSG 71 - 140 GLWRGDDDDEAAAAEMQRFSDLLQRLLNGIGGCSSSSDSGSAEKRRRKSPGGGGGGGSGNDNNQAATKSP 141 - 210 RKAAAAAARLNRLKKKEYVMGLESRVRGLAAENQELRAENRELGKRVQALQEESRYLRAVLANETGLARL 211 - 280 LSRLSGVGLRLTTSLFRDSPAGDHDYALPVGKQKQDLLEEDDSAGGVCLHVDKDKVSVEFCSACARKASS 281 - 350 SLKM 351 - 354 //
