Tbio SPANXA1 Sperm protein associated with the nucleus on the X chromosome A

Protein Summary

Description

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NS26
• Q5JWI0

Gene Name

• SPANXA1

Ensembl ID

• ENST00000370518
• ENSP00000359549
• ENSG00000203926
• ENST00000370519
• ENSP00000359550
• ENSG00000198021

Symbol

• SPANXA
• NAP-X
• SPANX
• CT11.1
• CT11.3
• SPAN-X
• SPAN-Xa
• SPAN-Xb
• SPANX-A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.38
disease	0.35
cell line	0.31
tissue	0.31
cellular component	0.3

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.3   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 16   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.3   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0