Tdark PLSCR2 Phospholipid scramblase 2

Protein Summary

Description

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain. This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q9NRY7
• B4DXC3
• J3KR76
• Q0VAQ1
• Q6NSW9
• Q7Z4L7
• PL scramblase 2

Gene Name

• PLSCR2

Ensembl ID

• ENST00000336685
• ENSP00000338707
• ENSG00000163746
• ENST00000497985
• ENSP00000420132
• ENST00000610787
• ENSP00000478044
• ENST00000613069
• ENSP00000478902

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.98
cell type or tissue	0.56
cell line	0.49
transcription factor	0.48
trait	0.46

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Phospholipid Scramblase 2

DTO Classes

Protein / Transporter / Phospholipid Scramblase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.77   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 22   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.77   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0