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Tbio
PLSCR4
Phospholipid scramblase 4

Protein Summary
Description
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354952
  • ENSP00000347038
  • ENSG00000114698
  • ENST00000433593
  • ENSP00000415605
  • ENST00000446574
  • ENSP00000399315
  • ENST00000493382
  • ENSP00000419040

Symbol
  • TRA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.98
gene perturbation
0.87
microRNA
0.72
virus perturbation
0.64
histone modification site profile
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.7   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.7   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0