Tchem LATS2 Serine/threonine-protein kinase LATS2

Protein Summary

Description

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NRM7
• B1AM47
• Q9P2X1

Gene Name

• LATS2

Ensembl ID

• ENST00000382592
• ENSP00000372035
• ENSG00000150457

Symbol

• KPM
• KPM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.94
transcription factor binding site profile	0.91
PubMedID	0.86
small molecule perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase Lats2

Protein / Transfer/carrier Protein / Serine/threonine-protein Kinase Lats2

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Serine/threonine-protein Kinase Lats2

Protein / Calcium-binding Protein / Annexin / Serine/threonine-protein Kinase Lats2

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Ndr Family / Serine/threonine-protein Kinase Lats2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.06   (req: < 5)

Gene RIFs: 136   (req: <= 3)

Antibodies: 294   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.06   (req: >= 5)

Gene RIFs: 136   (req: > 3)

Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0