Tbio | ATP-binding cassette sub-family B member 10, mitochondrial |
May mediate critical mitochondrial transport functions related to heme biosynthesis.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count |
---|---|
Colorectal Neoplasms | 217 |
Disease | Target Count | P-value |
---|---|---|
osteosarcoma | 7933 | 1.45698556829935E-7 |
ovarian cancer | 8492 | 6.01375589327355E-4 |
inflammatory breast cancer | 404 | 0.00370848419925237 |
pancreatic ductal adenocarcinoma liver metastasis | 1795 | 0.0179949482118864 |
aldosterone-producing adenoma | 664 | 0.0259408485379637 |
Rheumatoid Arthritis | 1171 | 0.0281895563354113 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Developmental coordination disorder | 8 | 8.073 | 4.0 |
Cerebral palsy | 28 | 3.778 | 1.9 |
Autism spectrum disorder | 17 | 3.63 | 1.8 |
Attention deficit hyperactivity disorder | 156 | 3.484 | 1.7 |
Disease | log2 FC | p |
---|---|---|
Rheumatoid Arthritis | 1.200 | 0.028 |
osteosarcoma | -2.897 | 0.000 |
pancreatic ductal adenocarcinoma liver m... | -1.591 | 0.018 |
aldosterone-producing adenoma | -1.018 | 0.026 |
inflammatory breast cancer | 1.100 | 0.004 |
ovarian cancer | 1.700 | 0.001 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
C. elegans | OMA Inparanoid |
S.cerevisiae | OMA Inparanoid |
PMID | Text |
---|---|
23720443 | ABCB10 is not a heme exporter but is required for the early mitochondrial steps of heme biosynthesis. |
23716676 | Data indicate that ABCB10 may exist in an open-inwards conformation when nucleotide is bound. |
22884976 | ABCB10 is required for primitive erythropoiesis and to protect from oxidative stress associated with cardiac ischemia-reperfusion in mice. Antioxidants can rescue the defects associated with ABCB10 loss-of-function in mice. |
22085049 | Human mitochondrial ATP-binding cassette transporter ABCB10 is required for efficient red blood cell development. |
20877624 | Observational study of gene-disease association. (HuGE Navigator) |
19343046 | Observational study of gene-disease association. (HuGE Navigator) |
19151771 | mutations in ABCB8 and ABCB10 is not associated with acute myeloid leukemia. |
15215243 | study of ABCB10 targeting, import, and dimerization |
MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLWGVGAARRWRS 1 - 70 GCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPGGPAAAAWAGDEAWRRGPAAP 71 - 140 PGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDN 141 - 210 LTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTA 211 - 280 LLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQA 281 - 350 TQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLL 351 - 420 MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQG 421 - 490 ALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQ 491 - 560 LNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEK 561 - 630 GVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANM 631 - 700 VAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA 701 - 738 //
PMID | Year | Title |
---|---|---|
25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
23720443 | 2013 | ATP-binding cassette B10 regulates early steps of heme synthesis. |
23716676 | 2013 | Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. |
23620142 | 2013 | Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. |
22884976 | 2012 | Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species. |
22085049 | 2012 | Human mitochondrial ATP-binding cassette transporter ABCB10 is required for efficient red blood cell development. |
21269460 | 2011 | Initial characterization of the human central proteome. |
20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. |
19608861 | 2009 | Lysine acetylation targets protein complexes and co-regulates major cellular functions. |
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