| Tbio | ATP-binding cassette sub-family B member 10, mitochondrial |
May mediate critical mitochondrial transport functions related to heme biosynthesis.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | 243 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 1.5e-07 |
| ovarian cancer | 8520 | 6.0e-04 |
| inflammatory breast cancer | 286 | 3.7e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.8e-02 |
| aldosterone-producing adenoma | 665 | 2.6e-02 |
| Rheumatoid arthritis | 1191 | 2.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Developmental coordination disorder | 8 | 8.15 | 4.0 |
| Attention deficit hyperactivity disorder | 278 | 3.884 | 1.9 |
| Cerebral palsy | 40 | 3.882 | 1.9 |
| Autism spectrum disorder | 101 | 3.63 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| aldosterone-producing adenoma | -1.018 | 2.6e-02 |
| inflammatory breast cancer | 1.100 | 3.7e-03 |
| osteosarcoma | -2.897 | 1.5e-07 |
| ovarian cancer | 1.700 | 6.0e-04 |
| pancreatic ductal adenocarcinoma liver m... | -1.591 | 1.8e-02 |
| Rheumatoid arthritis | 1.200 | 2.8e-02 |
MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLWGVGAARRWRS 1 - 70 GCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPGGPAAAAWAGDEAWRRGPAAP 71 - 140 PGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDN 141 - 210 LTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTA 211 - 280 LLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQA 281 - 350 TQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLL 351 - 420 MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQG 421 - 490 ALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQ 491 - 560 LNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEK 561 - 630 GVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANM 631 - 700 VAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSFISA 701 - 738 //
