| Tbio | Phosphoribosyltransferase domain-containing protein 1 |
Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Carcinoma, Squamous Cell | 110 | 0.0 | 0.0 |
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Mouth Neoplasms | 55 | 0.0 | 0.0 |
| Ovarian Neoplasms | 102 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Squamous cell carcinoma | 129 |
| ovarian neoplasm | 99 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 2.1e-27 |
| oligodendroglioma | 2850 | 1.8e-11 |
| non-small cell lung cancer | 2890 | 8.1e-10 |
| ependymoma | 4679 | 4.4e-07 |
| Astrocytoma, Pilocytic | 3081 | 4.5e-05 |
| Breast cancer | 3578 | 1.9e-03 |
| pancreatic cancer | 2398 | 3.2e-03 |
| pancreatic carcinoma | 562 | 3.2e-03 |
| gastric cancer | 459 | 1.0e-02 |
| invasive ductal carcinoma | 2951 | 1.0e-02 |
| acute myeloid leukemia | 783 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Lesch-Nyhan syndrome | 12 | 4.775 | 2.4 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -2.200 | 4.4e-02 |
| Astrocytoma, Pilocytic | 1.200 | 4.5e-05 |
| Breast cancer | -1.400 | 1.9e-03 |
| ependymoma | 1.200 | 4.4e-07 |
| gastric cancer | 1.200 | 1.0e-02 |
| invasive ductal carcinoma | -1.084 | 1.0e-02 |
| lung carcinoma | 1.900 | 2.1e-27 |
| non-small cell lung cancer | 1.013 | 8.1e-10 |
| oligodendroglioma | 1.100 | 1.8e-11 |
| pancreatic cancer | 1.500 | 3.2e-03 |
| pancreatic carcinoma | 1.500 | 3.2e-03 |
