Tbio | Phosphoribosyltransferase domain-containing protein 1 |
Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.
Comments
Disease | Target Count |
---|---|
Mouth Neoplasms | 44 |
Squamous cell carcinoma | 96 |
ovarian neoplasm | 97 |
post-traumatic stress disorder | 45 |
Disease | Target Count | P-value |
---|---|---|
lung carcinoma | 2844 | 2.12851519262371E-27 |
oligodendroglioma | 2849 | 1.81458223026258E-11 |
non-small cell lung cancer | 2798 | 8.0888449866721E-10 |
posterior fossa group B ependymoma | 1530 | 2.90776377180202E-7 |
pilocytic astrocytoma | 3086 | 6.62560587204672E-5 |
invasive ductal carcinoma | 2950 | 2.97800682441399E-4 |
Breast cancer | 3099 | 0.0019197947693461 |
pancreatic cancer | 2300 | 0.00316083769933163 |
pancreatic carcinoma | 567 | 0.0031608376993317 |
gastric cancer | 436 | 0.0100444760930101 |
acute myeloid leukemia | 785 | 0.0439083017023836 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Lesch-Nyhan syndrome | 12 | 4.77 | 2.4 |
Disease | log2 FC | p |
---|---|---|
gastric cancer | 1.200 | 0.010 |
pancreatic cancer | 1.500 | 0.003 |
oligodendroglioma | 1.100 | 0.000 |
posterior fossa group B ependymoma | 1.400 | 0.000 |
non-small cell lung cancer | 1.013 | 0.000 |
pilocytic astrocytoma | 1.200 | 0.000 |
pancreatic carcinoma | 1.500 | 0.003 |
invasive ductal carcinoma | -1.700 | 0.000 |
lung carcinoma | 1.900 | 0.000 |
Breast cancer | -1.400 | 0.002 |
acute myeloid leukemia | -2.200 | 0.044 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG |
Opossum | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA Inparanoid |
C. elegans | OMA EggNOG |
PMID | Text |
---|---|
25456346 | We found evidence for PRTFDC1 as a potential novel PTSD gene, a finding that awaits further replication. |
21818316 | These results demonstrate that PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse. |
21054786 | The PRTFDC1 structure has been determined at 1.7 A resolution with bound GMP. The overall structure and GMP binding mode are very similar to that observed for HPRT. |
17599052 | epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. |
PMID | Year | Title |
---|---|---|
25456346 | 2015 | Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. |
25416956 | 2014 | A proteome-scale map of the human interactome network. |
23934736 | 2013 | Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. |
23251661 | 2012 | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
21818316 | 2011 | PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse. |
21054786 | 2010 | Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1. |
19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
17599052 | 2007 | PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. |
17207965 | 2007 | hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. |
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