Tbio POLE3 DNA polymerase epsilon subunit 3

Protein Summary

Description

Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

Uniprot Accession IDs

• Q9NRF9
• Q5W0U1
• Q8N758
• Q8NCE5
• Q9NR32

Gene Name

• POLE3

Ensembl ID

• ENST00000374169
• ENSP00000363284
• ENSG00000148229
• ENST00000374171
• ENSP00000363286

Symbol

• CHRAC17
• p17
• YBL1
• CHRAC2
• CHRAC17
• CHARAC17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.97
kinase perturbation	0.91
histone modification site profile	0.89
transcription factor binding site profile	0.88
transcription factor perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0