Property Summary

NCBI Gene PubMed Count 14
PubMed Score 13.08
PubTator Score 24.83

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Stevens-Johnson syndrome 91
Disease Target Count P-value
psoriasis 6685 1.04563574932438E-24
breast carcinoma 1614 1.01269287560628E-18
Breast cancer 3099 5.4387936556312E-11
ulcerative colitis 2087 1.24737949791385E-8
juvenile dermatomyositis 1189 2.03474826807582E-8
tuberculosis 1563 5.47304903896497E-5
ovarian cancer 8492 2.87332789792834E-4
medulloblastoma, large-cell 6234 0.00205544862200487
active Crohn's disease 918 0.00835214936831336
interstitial cystitis 2299 0.0130117655823432
invasive ductal carcinoma 2950 0.0226015665750536
Disease Target Count Z-score Confidence
Mediastinitis 7 3.734 1.9

Expression

  Differential Expression (11)

Disease log2 FC p
medulloblastoma, large-cell -1.500 0.002
juvenile dermatomyositis 1.205 0.000
tuberculosis 2.100 0.000
active Crohn's disease 1.446 0.008
ulcerative colitis 2.000 0.000
interstitial cystitis 1.200 0.013
psoriasis 1.200 0.000
breast carcinoma 1.100 0.000
Breast cancer 1.400 0.000
invasive ductal carcinoma 1.100 0.023
ovarian cancer 1.400 0.000

Synonym

Accession Q9NRD1 B1AK42 B2RC88 Q9UKT3
Symbols FBG2
FBS2
FBX6
Fbx6b

Gene

  Ortholog (6)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Chicken OMA Inparanoid

Gene RIF (6)

PMID Text
25374377 It might inhibit cadmium-induced ER stress by functioning as a ubiquitin ligase in the ERAD system, thereby attenuating the cell death induced by subsequent JNK1 activation.
22292078 Two interacting proteins of human FBXO6 protein have been found using the service in the study.
22268729 systematical identification of the FBXO6-interacting glycoproteins, critical for clarifying its substrates as well as biological functions.
22190034 HIV-1 gp41 is identified to have a physical interaction with F-box protein 6 (FBXO6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses
19716789 Fbx6-dependent Chk1 degradation contributes to S phase checkpoint termination and that a defect in this mechanism might increase tumor cell resistance to certain anticancer drugs.
12939278 Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD

AA Sequence

MDAPHSKAALDSINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLMTLWKRKCLREGFITKDWDQ      1 - 70
PVADWKIFYFLRSLHRNLLRNPCAEEDMFAWQIDFNGGDRWKVESLPGAHGTDFPDPKVKKYFVTSYEMC     71 - 140
LKSQLVDLVAEGYWEELLDTFRPDIVVKDWFAARADCGCTYQLKVQLASADYFVLASFEPPPVTIQQWNN    141 - 210
ATWTEVSYTFSDYPRGVRYILFQHGGRDTQYWAGWYGPRVTNSSIVVSPKMTRNQASSEAQPGQKHGQEE    211 - 280
AAQSPYRAVVQIF                                                             281 - 293
//

Text Mined References (18)

PMID Year Title
25374377 2014 FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22292078 2012 SPPS: a sequence-based method for predicting probability of protein-protein interaction partners.
22268729 2012 Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.
21269460 2011 Initial characterization of the human central proteome.
19716789 2009 The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.
19028597 2009 Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.
18203720 2008 Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
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