Property Summary

NCBI Gene PubMed Count 15
Grant Count 20
R01 Count 2
Funding $2,599,881.8
PubMed Score 48.85
PubTator Score 22.20

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (2)

Expression

  Differential Expression (2)

Disease log2 FC p
pancreatic ductal adenocarcinoma liver m... -1.131 0.020
ovarian cancer -2.400 0.000

Gene RIF (4)

PMID Text
25801334 FBX8 was markedly down-regulated in gastric cancer tissues. Knocking down FBX8 promoted proliferation and invasion in tumor cell line. Patients with low FBX8 had poor prognosis.
25550853 FBX8 down-expression was an independent prognostic indicator for glioma patient's survival.
20848231 FBX8 is a novel c-Myc binding protein and that c-Myc induces cell invasive activity
18987618 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

AA Sequence

MGQGLWRVVRNQQLQQEGYSEQGYLTREQSRRMAASNISNTNHRKQVQGGIDIYHLLKARKSKEQEGFIN      1 - 70
LEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLD     71 - 140
EGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFL    141 - 210
PNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVK    211 - 280
NKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA                                   281 - 319
//

Text Mined References (17)

PMID Year Title
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
25801334 2015 Significance of FBX8 in progression of gastric cancer.
25550853 2014 Down-expression of F box only protein 8 correlates with tumor grade and poor prognosis in human glioma.
23400010 2014 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
20848231 2010 c-Myc stimulates cell invasion by inhibiting FBX8 function.
18987618 2009 Screening for replication of genome-wide SNP associations in sporadic ALS.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
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