Property Summary

NCBI Gene PubMed Count 52
PubMed Score 113.49
PubTator Score 73.59

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count
Mesothelioma 40
Disease Target Count P-value
lung carcinoma 2844 2.59730196924396E-12
astrocytoma 1493 9.92322907047935E-12
Breast cancer 3099 5.88582284483415E-9
pilocytic astrocytoma 3086 2.27580120705653E-8
ovarian cancer 8492 1.74978109067732E-7
oligodendroglioma 2849 4.55335420024521E-7
psoriasis 6685 8.34338122022661E-7
osteosarcoma 7933 1.92118096344659E-5
Amyotrophic Lateral Sclerosis 432 1.9857685389063E-5
cystic fibrosis 1670 3.35949506635204E-5
acute quadriplegic myopathy 1157 3.10829705101145E-4
ependymoma 2514 9.74777677494905E-4
group 4 medulloblastoma 1875 0.00101818608323305
glioblastoma 5572 0.00119660638735571
ductal carcinoma in situ 1745 0.00201413071259344
adult high grade glioma 2148 0.00380372679228242
pancreatic cancer 2300 0.00459462399654525
active ulcerative colitis 477 0.0046194911988591
atypical teratoid / rhabdoid tumor 4369 0.00512661603531068
invasive ductal carcinoma 2950 0.00594070799840469
primary pancreatic ductal adenocarcinoma 1271 0.00715720304269751
active Crohn's disease 918 0.00846984413567673
lung cancer 4473 0.00869732981230845
dermatomyositis 967 0.00992045416233986
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0111513615955576
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.0189235130517818
aldosterone-producing adenoma 664 0.0440928127404364
primitive neuroectodermal tumor 3031 0.0493869777176866
Disease Target Count Z-score Confidence
Acquired metabolic disease 267 0.0 2.0
Disease Target Count Z-score Confidence
Cleft palate 125 3.121 1.6
Cancer 2346 3.082 1.5



Accession Q9NRA1 B4DU34 B9EGR8 Q4W5M9 Q9UL22 PDGF-C
Symbols SCDGF


PANTHER Protein Class (2)

  Ortholog (13)

Gene RIF (41)

27033449 High glucose-mediated induction of PDGF-C via ChREBP in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes.
26687981 We conclude that PDGF-CC-induced blood-spinal cord barrier dysfunction can contribute to timing of amyotrophic lateral sclerosis onset
25383675 PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR, which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR).
24612214 Concomitant upregulation of PDGF-C with VEGF in Glioblastoma tumor cells.
24421315 Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and Bad phosphorylation.
24269585 Data indicate uPA (plau) and PAI1 (Serpine1) were up-regulated in human PDGF-C Tg mice, suggesting that uPA could be compensating for the loss of tissue-type plasminogen activator (tPA) activity in PDGF-C Tg; tpa KO mice.
24126726 The results indicate that PDGF-C upregulation and calpain-3 downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins
23929039 High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma.
23784143 Treatment of human neuroblastoma cells or rat primary neurons with HIV-1 Tat downregulates PDGF-C expression
23714575 PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review]

AA Sequence


Text Mined References (62)

PMID Year Title
27033449 2016 High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells.
26687981 2016 Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.
25383675 2014 Post-transcriptional up-regulation of PDGF-C by HuR in advanced and stressed breast cancer.
25108383 2014 Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
24612214 2014 Angiogenesis and expression of PDGF-C, VEGF, CD105 and HIF-1? in human glioblastoma.
24421315 2014 Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt and Bad phosphorylation.
24269585 2014 Tissue-type plasminogen activator is not necessary for platelet-derived growth factor-c activation.
24126726 2013 Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness.
23929039 2014 Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma.
23714575 2013 PDGF-C: a new performer in the neurovascular interplay.