Tbio XPNPEP1 Xaa-Pro aminopeptidase 1

Protein Summary

Description

Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q9NQW7
• A8K071
• G5E9Y2
• G8JLB2
• O15250
• Q53EX6
• Q8N3Q0
• Q96D23

Gene Name

• XPNPEP1

Ensembl ID

• ENST00000322238
• ENSP00000324011
• ENSG00000108039
• ENST00000502935
• ENSP00000421566

Symbol

• XPNPEPL
• XPNPEPL1
• APP1
• SAMP
• XPNPEP
• XPNPEPL
• XPNPEPL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor perturbation	0.96
disease perturbation	0.93
cell type or tissue	0.78
histone modification site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.96   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.96   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0