Tbio G6PC2 Glucose-6-phosphatase 2

Protein Summary

Description

May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NQR9
• E9PAX2
• Q6AHZ0
• G-6-Pase 2

Gene Name

• G6PC2

Ensembl ID

• ENST00000282075
• ENSP00000282075
• ENSG00000152254
• ENST00000375363
• ENSP00000364512
• ENST00000429379
• ENSP00000396939
• ENST00000612807
• ENSP00000481098
• ENSG00000278373
• ENST00000617403
• ENSP00000483899
• ENST00000622133
• ENSP00000482583

Symbol

• IGRP
• IGRP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.97
cellular component	0.66
phenotype	0.64
microRNA	0.62
disease	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.52   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.52   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0