| Tdark | Intraflagellar transport protein 46 homolog |
Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung cancer | 4473 | 0.00388782851551253 |
| ependymoma | 2514 | 0.0310944465919309 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Joubert syndrome | 62 | 4.327 | 2.2 |
| Meckel syndrome | 48 | 3.689 | 1.8 |
| Primary ciliary dyskinesia | 75 | 3.473 | 1.7 |
| Hydrocephalus | 60 | 3.392 | 1.7 |
| Nephronophthisis | 74 | 3.14 | 1.6 |
| Species | Source |
|---|---|
| Mouse | OMA Inparanoid |
| Rat | OMA Inparanoid |
| Dog | OMA Inparanoid |
| Horse | OMA Inparanoid |
| Cow | OMA Inparanoid |
| Opossum | OMA Inparanoid |
| Chicken | OMA Inparanoid |
| Anole lizard | OMA Inparanoid |
| PMID | Text |
|---|---|
| 17720815 | the ciliary protein IFT46 has a specific function in chondrocytes and is also essential for normal development of vertebrates. |
MADNSSDECEEENNKEKKKTSQLTPQRGFSENEDDDDDDDDSSETDSDSDDDDEEHGAPLEGAYDPADYE 1 - 70 HLPVSAEIKELFQYISRYTPQLIDLDHKLKPFIPDFIPAVGDIDAFLKVPRPDGKPDNLGLLVLDEPSTK 71 - 140 QSDPTVLSLWLTENSKQHNITQHMKVKSLEDAEKNPKAIDTWIESISELHRSKPPATVHYTRPMPDIDTL 141 - 210 MQEWSPEFEELLGKVSLPTAEIDCSLAEYIDMICAILDIPVYKSRIQSLHLLFSLYSEFKNSQHFKALAE 211 - 280 GKKAFTPSSNSTSQAGDMETLTFS 281 - 304 //
| PMID | Year | Title |
|---|---|---|
| 24339792 | 2013 | Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain. |
| 19253336 | 2009 | Characterization of mouse IFT complex B. |
| 17720815 | 2007 | Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish. |
| 16554811 | 2006 | Human chromosome 11 DNA sequence and analysis including novel gene identification. |
| 16381901 | 2006 | The LIFEdb database in 2006. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| 15489336 | 2004 | From ORFeome to biology: a functional genomics pipeline. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
| More... |
