Tdark | Intraflagellar transport protein 46 homolog |
Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity).
Comments
Disease | Target Count | P-value |
---|---|---|
lung cancer | 4473 | 0.00388782851551253 |
ependymoma | 2514 | 0.0310944465919309 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Joubert syndrome | 62 | 4.327 | 2.2 |
Meckel syndrome | 48 | 3.689 | 1.8 |
Primary ciliary dyskinesia | 75 | 3.473 | 1.7 |
Hydrocephalus | 60 | 3.392 | 1.7 |
Nephronophthisis | 74 | 3.14 | 1.6 |
Species | Source |
---|---|
Mouse | OMA Inparanoid |
Rat | OMA Inparanoid |
Dog | OMA Inparanoid |
Horse | OMA Inparanoid |
Cow | OMA Inparanoid |
Opossum | OMA Inparanoid |
Chicken | OMA Inparanoid |
Anole lizard | OMA Inparanoid |
PMID | Text |
---|---|
17720815 | the ciliary protein IFT46 has a specific function in chondrocytes and is also essential for normal development of vertebrates. |
MADNSSDECEEENNKEKKKTSQLTPQRGFSENEDDDDDDDDSSETDSDSDDDDEEHGAPLEGAYDPADYE 1 - 70 HLPVSAEIKELFQYISRYTPQLIDLDHKLKPFIPDFIPAVGDIDAFLKVPRPDGKPDNLGLLVLDEPSTK 71 - 140 QSDPTVLSLWLTENSKQHNITQHMKVKSLEDAEKNPKAIDTWIESISELHRSKPPATVHYTRPMPDIDTL 141 - 210 MQEWSPEFEELLGKVSLPTAEIDCSLAEYIDMICAILDIPVYKSRIQSLHLLFSLYSEFKNSQHFKALAE 211 - 280 GKKAFTPSSNSTSQAGDMETLTFS 281 - 304 //
PMID | Year | Title |
---|---|---|
24339792 | 2013 | Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain. |
19253336 | 2009 | Characterization of mouse IFT complex B. |
17720815 | 2007 | Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish. |
16554811 | 2006 | Human chromosome 11 DNA sequence and analysis including novel gene identification. |
16381901 | 2006 | The LIFEdb database in 2006. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
15489336 | 2004 | From ORFeome to biology: a functional genomics pipeline. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
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