Tbio TCF7L2 Transcription factor 7-like 2

Protein Summary

Description

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q9NQB0
• B4DRJ8
• B9X074
• C6ZRJ8
• C6ZRK0
• E2GH14
• E2GH19
• E2GH20
• E2GH24
• E2GH25
• E9PFH9
• F8W742
• F8W7T5
• O00185
• Q9NQB1
• Q9NQB2
• Q9NQB3
• Q9NQB4
• Q9NQB5
• Q9NQB6
• Q9NQB7
• Q9ULC2

Gene Name

• TCF7L2

Ensembl ID

• ENST00000352065
• ENSP00000344823
• ENSG00000148737
• ENST00000355717
• ENSP00000347949
• ENST00000355995
• ENSP00000348274
• ENST00000369397
• ENSP00000358404
• ENST00000538897
• ENSP00000446172
• ENST00000627217
• ENSP00000486891

Symbol

• TCF4
• TCF4
• TCF-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.97
transcription factor	0.94
transcription factor perturbation	0.94
trait	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 748.04   (req: < 5)

Gene RIFs: 639   (req: <= 3)

Antibodies: 402   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 748.04   (req: >= 5)

Gene RIFs: 639   (req: > 3)

Antibodies: 402   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0