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Tbio
SLC52A3
Solute carrier family 52, riboflavin transporter, member 3

Protein Summary
Description
Transporter for riboflavin, which must be obtained as a nutrient via intestinal absorption (PubMed:20463145, PubMed:24264046, PubMed:22273710, PubMed:27702554). Riboflavin transport is Na(+)-independent at low pH but significantly reduced by Na(+) depletion under neutral pH conditions (PubMed:24264046). This gene encodes a riboflavin transporter protein that is strongly expressed in the intestine and likely plays a role in intestinal absorption of riboflavin. The protein is predicted to have eleven transmembrane domains and a cell surface localization signal in the C-terminus. Mutations at this locus have been associated with Brown-Vialetto-Van Laere syndrome and Fazio-Londe disease. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217254
  • ENSP00000217254
  • ENSG00000101276
  • ENST00000381944
  • ENSP00000371370
  • ENST00000488495
  • ENSP00000494009
  • ENST00000632431
  • ENSP00000488723
  • ENST00000645534
  • ENSP00000494193

Symbol
  • C20orf54
  • RFT2
  • RFVT3
  • RFT2
  • BVVLS
  • RFVT3
  • hRFT2
  • BVVLS1
  • C20orf54
  • bA371L19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
pathway
0.78
tissue sample
0.68
PubMedID
0.63
gene perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.49   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.49   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0