| Tbio | A-kinase-interacting protein 1 |
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 4.7e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.7e-03 |
| colon cancer | 1478 | 1.4e-02 |
| subependymal giant cell astrocytoma | 2287 | 4.4e-02 |
| Disease | log2 FC | p |
|---|---|---|
| colon cancer | 1.200 | 1.4e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 3.7e-03 |
| osteosarcoma | -1.115 | 4.7e-04 |
| subependymal giant cell astrocytoma | 1.040 | 4.4e-02 |
