Tbio | A-kinase-interacting protein 1 |
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Comments
Disease | Target Count | P-value |
---|---|---|
osteosarcoma | 7933 | 4.68319893503613E-4 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.00371865473933646 |
colon cancer | 1475 | 0.0136291271536376 |
subependymal giant cell astrocytoma | 2287 | 0.0439452106393112 |
Disease | log2 FC | p |
---|---|---|
osteosarcoma | -1.115 | 0.000 |
intraductal papillary-mucinous neoplasm ... | 1.200 | 0.004 |
colon cancer | 1.200 | 0.014 |
subependymal giant cell astrocytoma | 1.040 | 0.044 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
PMID | Text |
---|---|
25526186 | The absence of exon 3 and exon 5 influenced the subcellular localization of BCA3 and nuclear factor kappa B (NF-kB)-dependent gene expression. |
24886575 | HIV-1 PR(D25N) directly interacts with BCA3 in cells and co-localizes with BCA3 in the cytoplasm, particularly at the mitochondria |
24659101 | Expression of BCA3 did not affect Mason-Pfizer money virus (MPMV) particle release and proteolytic processing; however, it slightly increased MPMV infectivity. |
24413079 | Data indicate an important role for A-kinase-interacting protein 1 (AKIP1) in esophageal squamous cell carcinoma (ESCC) angiogenesis and lymphangiogenesis. |
23319652 | Data indicate A-kinase interacting protein 1 (AKIP1) as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart. |
20628086 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
20562110 | action of PKA signaling on the NF-kappaB activation cascade |
19913121 | Observational study of gene-disease association. (HuGE Navigator) |
18178962 | AKIP1 colocalized with p65 within the cells and appeared to retain p65 in nucleus. |
15630084 | AKIP1 describes a PKA-interacting protein that can contribute to localization by a mechanism that is distinct from A-kinase anchoring proteins that interact with the regulatory subunits. |
More... |
PMID | Year | Title |
---|---|---|
25526186 | 2014 | Cloning and functional identification of a novel BCA3 splice. |
24659101 | 2014 | Breast cancer-associated protein--a novel binding partner of Mason-Pfizer monkey virus protease. |
24413079 | 2015 | Overexpression of AKIP1 promotes angiogenesis and lymphangiogenesis in human esophageal squamous cell carcinoma. |
23319652 | 2013 | A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. |
20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |
20562110 | 2010 | A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling. |
19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |
18178962 | 2008 | AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65. |
17207965 | 2007 | hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. |
15630084 | 2005 | A-kinase-interacting protein localizes protein kinase A in the nucleus. |
More... |