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Tbio A-kinase-interacting protein 1

Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.

This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

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Property Summary

NCBI Gene PubMed Count 17
Grant Count 12
R01 Count 7
Funding $677,240.56
PubMed Score 17.64
PubTator Score 12.29

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (5)

Disease Z-score Confidence
Cancer 2,346 4.0
colon cancer 1,475
intraductal papillary-mucinous neoplasm ... 3,289 
osteosarcoma 7,933
subependymal giant cell astrocytoma 2,287

Expression

  Differential Expression (4)

Disease log2 FC p
osteosarcoma -1.115 0.000
intraductal papillary-mucinous neoplasm ... 1.200 0.004
colon cancer 1.200 0.014
subependymal giant cell astrocytoma 1.040 0.044

Synonym

Accession Q9NQ31 Q8NBS2 Q8TAC6 Q8TAD3 Q8TAE0
Symbols BCA3
C11orf17

Gene

AKIP1

 Grant Application (12)

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 GO Component (1)

 GO Process (2)

 Compartment GO Term (18)

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 MGI Term (1)

Pathway (1)

 UniProt Keyword (6)

Gene RIF (11)

PMID Text
25526186 The absence of exon 3 and exon 5 influenced the subcellular localization of BCA3 and nuclear factor kappa B (NF-kB)-dependent gene expression.
24886575 HIV-1 PR(D25N) directly interacts with BCA3 in cells and co-localizes with BCA3 in the cytoplasm, particularly at the mitochondria
24659101 Expression of BCA3 did not affect Mason-Pfizer money virus (MPMV) particle release and proteolytic processing; however, it slightly increased MPMV infectivity.
24413079 Data indicate an important role for A-kinase-interacting protein 1 (AKIP1) in esophageal squamous cell carcinoma (ESCC) angiogenesis and lymphangiogenesis.
23319652 Data indicate A-kinase interacting protein 1 (AKIP1) as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20562110 action of PKA signaling on the NF-kappaB activation cascade
19913121 Observational study of gene-disease association. (HuGE Navigator)
18178962 AKIP1 colocalized with p65 within the cells and appeared to retain p65 in nucleus.
15630084 AKIP1 describes a PKA-interacting protein that can contribute to localization by a mechanism that is distinct from A-kinase anchoring proteins that interact with the regulatory subunits.
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AA Sequence 

MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLEKQPAAGPQRV      1 - 70
LPGEREERPPTLSASFRTMAEFMDYTSSQCGKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQRKDR     71 - 140
KKTSLGPGGSYQISEHAPEASQPAENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVAVDSGQSVDLVFPV    141 - 210
//

Text Mined References (17)

PMID Year Title
25526186 2014 Cloning and functional identification of a novel BCA3 splice.
24659101 2014 Breast cancer-associated protein--a novel binding partner of Mason-Pfizer monkey virus protease.
24413079 2015 Overexpression of AKIP1 promotes angiogenesis and lymphangiogenesis in human esophageal squamous cell carcinoma.
23319652 2013 A kinase interacting protein (AKIP1) is a key regulator of cardiac stress.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20562110 2010 A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
18178962 2008 AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
15630084 2005 A-kinase-interacting protein localizes protein kinase A in the nucleus.
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