Tdark NXT2 NTF2-related export protein 2

Protein Summary

Description

Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export. The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q9NPJ8
• D3DUY1
• Q0VAN8
• Q5JYV5
• Q5JYV6
• Q5JYV7
• Q9H8U0
• Q9NQ64
• Q9NRL7
• Q9Y3M4
• Q9Y3M5

Gene Name

• NXT2

Ensembl ID

• ENST00000218004
• ENSP00000218004
• ENSG00000101888
• ENST00000372103
• ENSP00000361175
• ENST00000372106
• ENSP00000361178
• ENST00000372107
• ENSP00000361179

Symbol

• P15-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
microRNA	0.69
kinase perturbation	0.6
tissue sample	0.59
cell line	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.41   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 34   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.41   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0