Tbio MED4 Mediator of RNA polymerase II transcription subunit 4

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q9NPJ6
• B4DX67
• Q53GB4
• Q53H68
• Q5T912
• Q6FHC4
• Q6IA79
• Q9BS95
• Q9NYR5

Gene Name

• MED4

Ensembl ID

• ENST00000258648
• ENSP00000258648
• ENSG00000136146
• ENST00000378586
• ENSP00000367849

Symbol

• ARC36
• DRIP36
• VDRIP
• ARC36
• VDRIP
• DRIP36
• TRAP36
• HSPC126

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
kinase perturbation	0.98
transcription factor binding site profile	0.94
protein complex	0.78
hub protein	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.49   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.49   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0