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Tbio Interleukin-26

May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.

This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 28
Grant Count 7
R01 Count 7
Funding $652,640.06
PubMed Score 32.10
PubTator Score 33.83

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (7)

Disease Z-score Confidence
Crohn's disease 304 3.525 1.8
psoriasis 6,685 3.2 1.6
Atopic dermatitis 944
cystic fibrosis 1,665
group 3 medulloblastoma 2,254
interstitial cystitis 2,299
ulcerative colitis 2,087 2.0

Expression

  Differential Expression (5)

Disease log2 FC p
cystic fibrosis -1.727 0.000
Atopic dermatitis 1.200 0.000
interstitial cystitis 1.500 0.030
group 3 medulloblastoma 1.900 0.008
psoriasis 4.500 0.000

Synonym

Accession Q9NPH9 IL-26
Symbols AK155
IL-26

Gene

IL26

PANTHER Protein Class (3)

 Grant Application (7)

 GO Function (1)

 GO Component (2)

 GO Process (10)

 Compartment GO Term (11)

Pathway (1)

 UniProt Keyword (5)

Gene RIF (17)

PMID Text
27029915 Our study indicates that IL-26 is a potential biomarker of disease severity in pediatric asthma without signs of Th2-mediated inflammation.
26202572 IL-26 is emerging as a potentially important player in host defense and may also be a pathogenic factor in the chronic inflammatory disorders of humans. [Review]
25157980 The negative influence of IL-26 on the anti-mycobacterial activity and its constitutive presence in both serum and monocyte supernatants prompt a proposal that IL26 as a candidate gene for tuberculosis susceptibility.
23875025 IL-26 differentially modulates the infection by different enveloped viruses.
23704922 Elevated levels of IL-26 in human gastric cancer promote proliferation and survival by modulating STAT1/STAT3 signaling.
23055831 IL-26 appears as a novel proinflammatory cytokine, located upstream of the proinflammatory cascade, that may constitute a promising target to treat rheumatoid arthritis and chronic inflammatory disorders.
22622197 Identify a second enhancer element positioned between IL26 and IFNG required for both IL26 and IFNG expression. One function of this enhancer is to facilitate recruitment of RNA polymerase II to promoters of both genes.
20503287 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20237496 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence 

MLVNFILRCGLLLVTLSLAIAKHKQSSFTKSCYPRGTLSQAVDALYIKAAWLKATIPEDRIKNIRLLKKK      1 - 70
TKKQFMKNCQFQEQLLSFFMEDVFGQLQLQGCKKIRFVEDFHSLRQKLSHCISCASSAREMKSITRMKRI     71 - 140
FYRIGNKGIYKAISELDILLSWIKKLLESSQ                                           141 - 171
//

Text Mined References (28)

PMID Year Title
27029915 2016 The cytokine interleukin-26 as a biomarker in pediatric asthma.
26202572 2016 Interleukin-26: An Emerging Player in Host Defense and Inflammation.
25157980 2015 Microarray analysis of Mycobacterium tuberculosis-infected monocytes reveals IL26 as a new candidate gene for tuberculosis susceptibility.
23875025 2013 The cationic cytokine IL-26 differentially modulates virus infection in culture.
23704922 2013 IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation.
23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
23055831 2012 IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation.
22622197 2012 Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element.
21297633 2011 Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
20503287 2010 Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
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