Tbio | Interleukin-26 |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
Atopic dermatitis | 944 | 6.80653947552787E-5 |
cystic fibrosis | 1670 | 3.46829498839509E-4 |
group 3 medulloblastoma | 2254 | 0.00824110003729349 |
interstitial cystitis | 2299 | 0.0303072461167273 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
ulcerative colitis | 2087 | 0.0 | 2.0 |
Disease | log2 FC | p |
---|---|---|
cystic fibrosis | -1.727 | 0.000 |
Atopic dermatitis | 1.200 | 0.000 |
interstitial cystitis | 1.500 | 0.030 |
group 3 medulloblastoma | 1.900 | 0.008 |
psoriasis | 4.500 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG |
PMID | Text |
---|---|
27029915 | Our study indicates that IL-26 is a potential biomarker of disease severity in pediatric asthma without signs of Th2-mediated inflammation. |
26202572 | IL-26 is emerging as a potentially important player in host defense and may also be a pathogenic factor in the chronic inflammatory disorders of humans. [Review] |
25157980 | The negative influence of IL-26 on the anti-mycobacterial activity and its constitutive presence in both serum and monocyte supernatants prompt a proposal that IL26 as a candidate gene for tuberculosis susceptibility. |
23875025 | IL-26 differentially modulates the infection by different enveloped viruses. |
23704922 | Elevated levels of IL-26 in human gastric cancer promote proliferation and survival by modulating STAT1/STAT3 signaling. |
23055831 | IL-26 appears as a novel proinflammatory cytokine, located upstream of the proinflammatory cascade, that may constitute a promising target to treat rheumatoid arthritis and chronic inflammatory disorders. |
22622197 | Identify a second enhancer element positioned between IL26 and IFNG required for both IL26 and IFNG expression. One function of this enhancer is to facilitate recruitment of RNA polymerase II to promoters of both genes. |
20503287 | Observational study of gene-disease association. (HuGE Navigator) |
20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
20237496 | Observational study of gene-disease association. (HuGE Navigator) |
More... |
PMID | Year | Title |
---|---|---|
27029915 | 2016 | The cytokine interleukin-26 as a biomarker in pediatric asthma. |
26202572 | 2016 | Interleukin-26: An Emerging Player in Host Defense and Inflammation. |
25157980 | 2015 | Microarray analysis of Mycobacterium tuberculosis-infected monocytes reveals IL26 as a new candidate gene for tuberculosis susceptibility. |
23875025 | 2013 | The cationic cytokine IL-26 differentially modulates virus infection in culture. |
23704922 | 2013 | IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation. |
23128233 | 2012 | Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. |
23055831 | 2012 | IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. |
22622197 | 2012 | Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element. |
21297633 | 2011 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. |
20503287 | 2010 | Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. |
More... |