Tchem SLCO1B3 Solute carrier organic anion transporter family member 1B3

Protein Summary

Description

Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• Q9NPD5
• E7EMT8
• Q5JAR4

Gene Name

• SLCO1B3

Ensembl ID

• ENST00000261196
• ENSP00000261196
• ENSG00000111700
• ENST00000381545
• ENSP00000370956

Symbol

• LST2
• OATP1B3
• OATP8
• SLC21A8
• LST3
• HBLRR
• LST-2
• OATP8
• OATP-8
• OATP1B3
• SLC21A8
• LST-3TM13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	0.95
cell type or tissue	0.8
biological term	0.78
chemical	0.68
disease	0.58

Protein Classes

PANTHER Classes

Protein / Transporter / Solute Carrier Organic Anion Transporter Family Member 1b3

Protein / ... / Protease Inhibitor / Solute Carrier Organic Anion Transporter Family Member 1b3

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slco Family Of Organic Anion Transporting Polypeptides / Solute Carrier Organic Anion Transporter Family Member 1b3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.5   (req: < 5)

Gene RIFs: 132   (req: <= 3)

Antibodies: 210   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.5   (req: >= 5)

Gene RIFs: 132   (req: > 3)

Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9