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Tbio E3 ubiquitin-protein ligase CCNB1IP1

E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]

 Comments

Property Summary

NCBI Gene PubMed Count 17
PubMed Score 11.99
PubTator Score 7.87

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
Breast cancer 3099 2.01501414678851E-13
sonic hedgehog group medulloblastoma 1482 9.88243177387446E-8
invasive ductal carcinoma 2950 6.5785159270212E-4
Multiple myeloma 1328 0.00231345386005773
ovarian cancer 8492 0.016070394667686

Expression

  Differential Expression (5)

Disease log2 FC p
Multiple myeloma 1.753 0.002
sonic hedgehog group medulloblastoma 2.100 0.000
invasive ductal carcinoma -1.382 0.001
Breast cancer -1.300 0.000
ovarian cancer 1.100 0.016

Synonym

Accession Q9NPC3
Symbols HEI10
C14orf18

Gene

CCNB1IP1

  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

 GO Function (3)

 GO Component (1)

 GO Process (5)

 Compartment GO Term (18)

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 MGI Term (2)

 HCA RNA Cell Line (56)

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Pathway (3)

 UniProt Keyword (13)

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Gene RIF (2)

PMID Text
16532029 The cyclin B-binding protein and cell cycle regulator HEI10 is identified as a novel merlin-binding partner; interaction with merlin affects HEI10 protein levels.
12612082 HEI10 defines a divergent class of E3 ubiquitin ligase, functioning in progression through G(2)/M.

AA Sequence 

MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRSPAICPACNSTLSGKLDIVRTELSPSE      1 - 70
EYKAMVLAGLRPEIVLDISSRALAFWTYQVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMK     71 - 140
GEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPL    141 - 210
GNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTAPEPSNSFFSFVSPSRELEQQQVSSRAFKVKRI       211 - 277
//

Text Mined References (19)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
21779533 2010 Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17297447 2007 HEI10 negatively regulates cell invasion by inhibiting cyclin B/Cdk1 and other promotility proteins.
16712791 2006 Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
16532029 2006 A functional association between merlin and HEI10, a cell cycle regulator.
16381901 2006 The LIFEdb database in 2006.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16341674 2005 Transcriptome analysis of human gastric cancer.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
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