| Tbio | E3 ubiquitin-protein ligase CCNB1IP1 |
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]
HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3577 | 2.0e-13 |
| invasive ductal carcinoma | 2950 | 6.6e-04 |
| Multiple myeloma | 1332 | 2.3e-03 |
| medulloblastoma | 720 | 5.2e-03 |
| ovarian cancer | 8519 | 1.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Intravenous leiomyomatosis | 3 | 3.823 | 1.9 |
| Smooth muscle tumor | 13 | 3.463 | 1.7 |
| Uterine fibroid | 28 | 3.414 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | -1.300 | 2.0e-13 |
| invasive ductal carcinoma | -1.382 | 6.6e-04 |
| medulloblastoma | 1.100 | 5.2e-03 |
| Multiple myeloma | 1.753 | 2.3e-03 |
| ovarian cancer | 1.100 | 1.6e-02 |
MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRSPAICPACNSTLSGKLDIVRTELSPSE 1 - 70 EYKAMVLAGLRPEIVLDISSRALAFWTYQVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMK 71 - 140 GEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPL 141 - 210 GNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTAPEPSNSFFSFVSPSRELEQQQVSSRAFKVKRI 211 - 277 //
