Property Summary

NCBI Gene PubMed Count 17
Grant Count 6
R01 Count 6
Funding $217,373.78
PubMed Score 11.99
PubTator Score 7.87

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (5)

Disease log2 FC p
Multiple myeloma 1.753 0.002
sonic hedgehog group medulloblastoma 2.100 0.000
invasive ductal carcinoma -1.382 0.001
Breast cancer -1.300 0.000
ovarian cancer 1.100 0.016

Gene RIF (2)

PMID Text
16532029 The cyclin B-binding protein and cell cycle regulator HEI10 is identified as a novel merlin-binding partner; interaction with merlin affects HEI10 protein levels.
12612082 HEI10 defines a divergent class of E3 ubiquitin ligase, functioning in progression through G(2)/M.

AA Sequence

MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRSPAICPACNSTLSGKLDIVRTELSPSE      1 - 70
EYKAMVLAGLRPEIVLDISSRALAFWTYQVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKDVELTSMK     71 - 140
GEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPL    141 - 210
GNNSKFPLDNTPVRNRGDGDGDFQFRPFFAGSPTAPEPSNSFFSFVSPSRELEQQQVSSRAFKVKRI       211 - 277
//

Text Mined References (19)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
21779533 2010 Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17297447 2007 HEI10 negatively regulates cell invasion by inhibiting cyclin B/Cdk1 and other promotility proteins.
16712791 2006 Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
16532029 2006 A functional association between merlin and HEI10, a cell cycle regulator.
16381901 2006 The LIFEdb database in 2006.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16341674 2005 Transcriptome analysis of human gastric cancer.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
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