Tbio POLM DNA-directed DNA/RNA polymerase mu

Protein Summary

Description

Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.

Uniprot Accession IDs

• Q9NP87
• D3DVK4
• Q6P5X8
• Q86WQ9
• Pol Mu

Gene Name

• POLM

Ensembl ID

• ENST00000242248
• ENSP00000242248
• ENSG00000122678
• ENST00000335195
• ENSP00000335141
• ENST00000395831
• ENSP00000379174

Symbol

• polmu
• Tdt-N
• Pol Mu

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
disease perturbation	0.74
histone modification site profile	0.74
tissue sample	0.74
transcription factor binding site profile	0.67

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna-directed Dna Polymerase / Dna-directed Dna/rna Polymerase Mu

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Dna Polymerase / Dna-directed Dna/rna Polymerase Mu

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.6   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.6   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0