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Tdark Calcium-binding protein 5

Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity).

The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. [provided by RefSeq, Oct 2009]

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 4.90
PubTator Score 2.39

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
medulloblastoma, large-cell 6241 5.5e-04
pancreatic cancer 2398 3.5e-02
pancreatic carcinoma 562 3.5e-02
group 3 medulloblastoma 4104 4.8e-02
Disease Target Count Z-score Confidence
Attention deficit hyperactivity disorder 278 0.0 3.0
Disease Target Count Z-score Confidence
Amebiasis 21 3.96 2.0

Expression

  Differential Expression (4)

Disease log2 FC p
group 3 medulloblastoma 1.600 4.8e-02
medulloblastoma, large-cell 1.900 5.5e-04
pancreatic cancer 1.300 3.5e-02
pancreatic carcinoma 1.300 3.5e-02

Synonym

Accession Q9NP86 A0AUY4 CaBP5
Symbols CABP3

Gene

CABP5

  Ortholog (10)

Species Source Disease
OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA

 UniProt Keyword (7)

 GO Function (1)

 GO Component (1)

 GO Process (1)

 Compartment GO Term (8)

 GWAS Trait (1)

 HCA RNA Cell Line (3)

Protein-protein Interaction (1)

SQOR  

Gene RIF (1)

AA Sequence 

MQFPMGPACIFLRKGIAEKQRERPLGQDEIEELREAFLEFDKDRDGFISCKDLGNLMRTMGYMPTEMELI      1 - 70
ELGQQIRMNLGGRVDFDDFVELMTPKLLAETAGMIGVQEMRDAFKEFDTNGDGEITLVELQQAMQRLLGE     71 - 140
RLTPREISEVVREADVNGDGTVDFEEFVKMMSR                                         141 - 173
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Text Mined References (11)

PMID Year Title