Tbio | Calcium-binding protein 5 |
Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity).
The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. [provided by RefSeq, Oct 2009]
The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. [provided by RefSeq, Oct 2009]
Comments
Disease | Target Count | P-value |
---|---|---|
medulloblastoma, large-cell | 6234 | 5.53592977531043E-4 |
pancreatic cancer | 2300 | 0.0345539403562465 |
pancreatic carcinoma | 567 | 0.0345539403562466 |
group 3 medulloblastoma | 2254 | 0.0478642852484457 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Attention deficit hyperactivity disorder | 156 | 0.0 | 2.0 |
Disease | log2 FC | p |
---|---|---|
pancreatic cancer | 1.300 | 0.035 |
medulloblastoma, large-cell | 1.900 | 0.001 |
group 3 medulloblastoma | 1.600 | 0.048 |
pancreatic carcinoma | 1.300 | 0.035 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG |
Platypus | OMA EggNOG Inparanoid |
Anole lizard | OMA Inparanoid |
PMID | Text |
---|---|
24599957 | the faster migrating Tg adduct C primarily engages the CaBP1/P5 oxidoreductase, whereas the slower migrating Tg adduct A primarily engages ERp72. |
PMID | Year | Title |
---|---|---|
25416956 | 2014 | A proteome-scale map of the human interactome network. |
24599957 | 2014 | Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum. |
19338761 | 2009 | Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. |
18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
11785943 | 2002 | Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. |
11108966 | 2000 | Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). |
10625670 | 2000 | Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. |
8889548 | 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. |
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