| Tdark | Calcium-binding protein 5 |
Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity).
The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. [provided by RefSeq, Oct 2009]
The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. [provided by RefSeq, Oct 2009]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6241 | 5.5e-04 |
| pancreatic cancer | 2398 | 3.5e-02 |
| pancreatic carcinoma | 562 | 3.5e-02 |
| group 3 medulloblastoma | 4104 | 4.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Attention deficit hyperactivity disorder | 278 | 0.0 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.600 | 4.8e-02 |
| medulloblastoma, large-cell | 1.900 | 5.5e-04 |
| pancreatic cancer | 1.300 | 3.5e-02 |
| pancreatic carcinoma | 1.300 | 3.5e-02 |
