Tbio ABCB9 ATP-binding cassette sub-family B member 9

Protein Summary

Description

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• Q9NP78
• B4E2J0
• Q5W9G7
• Q769F3
• Q769F4
• Q96AB1
• Q9P208

Gene Name

• ABCB9

Ensembl ID

• ENST00000280560
• ENSP00000280560
• ENSG00000150967
• ENST00000344275
• ENSP00000456813
• ENST00000346530
• ENSP00000280559
• ENST00000392439
• ENSP00000376234
• ENST00000442833
• ENSP00000456375
• ENST00000540285
• ENSP00000441734
• ENST00000542678
• ENSP00000440288

Symbol

• KIAA1520
• TAPL
• EST122234

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
co-expressed gene	0.91
cellular component	0.86
protein domain	0.85
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Atp-binding Cassette Sub-family B Member 9

Protein / ... / Cysteine Protease / Atp-binding Cassette Sub-family B Member 9

DTO Classes

Protein / Transporter / Atp-binding Cassette Transporter Family / Abcb Subfamily / Atp-binding Cassette Sub-family B Member 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.13   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.13   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0