SINHCAF
SIN3-HDAC complex-associated factor
Protein Summary
Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity).
- ENST00000337682
- ENSP00000337477
- ENSG00000139146
- ENST00000454658
- ENSP00000393279
- ENST00000539409
- ENSP00000443697
- ENST00000542983
- ENSP00000439952
- ENST00000617411
- ENSP00000479093
- ENSG00000276371
- ENST00000631598
- ENSP00000488852
- ENST00000633702
- ENSP00000488570
- ENST00000633815
- ENSP00000488406
- C12orf14
- FAM60A
- L4
- TERA
- FAM60A
- C12orf14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.59 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 42 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.59 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 42 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0