Property Summary

NCBI Gene PubMed Count 35
Grant Count 37
R01 Count 31
Funding $3,402,499.85
PubMed Score 41.62
PubTator Score 39.46

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (7)

Disease log2 FC p
cutaneous lupus erythematosus 2.300 0.000
medulloblastoma, large-cell 1.500 0.000
tuberculosis and treatment for 6 months -1.900 0.000
lung cancer -1.100 0.002
interstitial cystitis 1.100 0.001
ovarian cancer 1.100 0.000
psoriasis 2.400 0.000

Gene RIF (20)

PMID Text
26163016 TSAD binds to and co-localizes with Nck. Expression of TSAD increases both Nck-Lck and Nck-SLP-76 interaction in T cells.
25492967 The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
24910151 Data indicate the expression pattern of T cell-specific adapter protein (TSAd) in various healthy lymphoid and non-lymphoid tissues.
21696499 in chronic inflammatory demyelinating polyneuropathy we found an association with a homozygous genotype for a low repeat number of tandem GA in the SH2D2A gene
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20305788 TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements
19913121 Observational study of gene-disease association. (HuGE Navigator)
19561400 TSAd associates with laminin binding protein and mediates T lymphocyte migration during T cell activation
19240061 Observational study of gene-disease association. (HuGE Navigator)
18554728 the present study shows that the SH2D2A gene may contribute to susceptibility to MS.
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AA Sequence

MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAASNTGNAERAEEVPGEGSLFL      1 - 70
QAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRH     71 - 140
FLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTPEPAGLSLRTEESNFGSKSQ    141 - 210
DPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIPAKPQLPPEVYTIPVPRHRPAPRPKPSNPIY    211 - 280
NEPDEPIAFYAMGRGSPGEAPSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ    281 - 350
GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ                                   351 - 389
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Text Mined References (36)

PMID Year Title
26163016 2015 T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells.
25814554 2015 Phospho-tyrosine dependent protein-protein interaction network.
25492967 2014 The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
25416956 2014 A proteome-scale map of the human interactome network.
24910151 2014 Expression of the T cell-specific adapter protein in human tissues.
24728074 2014 Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
21696499 2011 Polymorphism of CD1 and SH2D2A genes in inflammatory neuropathies.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20305788 2010 T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
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