SH2D2A
SH2 domain-containing protein 2A
Protein Summary
Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
- ENST00000368198
- ENSP00000357181
- ENSG00000027869
- ENST00000368199
- ENSP00000357182
- ENST00000392306
- ENSP00000376123
- SCAP
- TSAD
- VRAP
- SCAP
- TSAD
- VRAP
- F2771
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.72 | ||
gene perturbation | 0.64 | ||
tissue sample | 0.54 | ||
hub protein | 0.53 | ||
tissue | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 59.33 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 295 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 59.33 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 295 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0