Protein Summary
Involved in the mineralization and structural organization of enamel. Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]
- ENST00000368848
- ENSP00000357841
- ENSG00000143367
- ENST00000368849
- ENSP00000357842
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.98 | ||
kinase perturbation | 0.91 | ||
small molecule perturbation | 0.88 | ||
transcription factor perturbation | 0.8 | ||
PubMedID | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 66.58 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 110 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 66.58 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 110 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0