| Tdark | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| glioblastoma | 5792 | 4.2e-09 |
| group 3 medulloblastoma | 4104 | 2.8e-08 |
| medulloblastoma, large-cell | 6241 | 1.0e-07 |
| adult high grade glioma | 3801 | 6.9e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.9e-06 |
| Astrocytoma, Pilocytic | 3081 | 4.0e-06 |
| ependymoma | 4679 | 1.3e-03 |
| astrocytic glioma | 2597 | 2.4e-03 |
| Pick disease | 1894 | 9.9e-03 |
| oligodendroglioma | 2850 | 1.0e-02 |
| subependymal giant cell astrocytoma | 2287 | 2.0e-02 |
| primitive neuroectodermal tumor | 3035 | 3.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -3.400 | 6.9e-07 |
| astrocytic glioma | -3.300 | 2.4e-03 |
| Astrocytoma, Pilocytic | -1.500 | 4.0e-06 |
| atypical teratoid / rhabdoid tumor | -3.500 | 2.9e-06 |
| ependymoma | -4.000 | 1.3e-03 |
| glioblastoma | -3.300 | 4.2e-09 |
| group 3 medulloblastoma | -4.600 | 2.8e-08 |
| medulloblastoma, large-cell | -4.100 | 1.0e-07 |
| oligodendroglioma | -2.700 | 1.0e-02 |
| Pick disease | -1.500 | 9.9e-03 |
| primitive neuroectodermal tumor | -1.500 | 3.2e-02 |
| subependymal giant cell astrocytoma | -2.853 | 2.0e-02 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
