| Tbio | O-phosphoseryl-tRNA(Sec) selenium transferase |
Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011]
The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| PONTOCEREBELLAR HYPOPLASIA, TYPE 2D | 1 | 0.0 | 0.0 |
| Weight Gain | 100 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 5.2e-08 |
| ovarian cancer | 8520 | 1.9e-07 |
| tuberculosis | 2010 | 8.8e-06 |
| glioblastoma | 5792 | 5.7e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.8e-04 |
| pediatric high grade glioma | 1064 | 3.1e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 8.3e-04 |
| primitive neuroectodermal tumor | 3035 | 8.7e-04 |
| osteosarcoma | 7950 | 2.3e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.6e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.8e-03 |
| sonic hedgehog group medulloblastoma | 467 | 1.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Pontocerebellar hypoplasia | 36 | 3.656 | 1.8 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Intellectual disability | 1016 | 0.0 | 4.0 |
| Neurodegenerative disease | 414 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Autoimmune hepatitis | 11 | 7.115 | 3.6 |
| Liver disease | 237 | 4.876 | 2.4 |
| Primary sclerosing cholangitis | 14 | 4.576 | 2.3 |
| Amelogenesis imperfecta | 29 | 4.407 | 2.2 |
| Hepatitis C | 94 | 3.322 | 1.7 |
| Disease | Target Count |
|---|---|
| Pontocerebellar hypoplasia type 2D | 1 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.400 | 2.8e-04 |
| ependymoma | 1.200 | 5.2e-08 |
| glioblastoma | 1.100 | 5.7e-05 |
| intraductal papillary-mucinous adenoma (... | 1.500 | 8.3e-04 |
| intraductal papillary-mucinous neoplasm ... | 1.500 | 2.8e-03 |
| osteosarcoma | -1.286 | 2.3e-03 |
| ovarian cancer | -1.500 | 1.9e-07 |
| pancreatic ductal adenocarcinoma liver m... | -1.556 | 2.6e-03 |
| pediatric high grade glioma | 1.100 | 3.1e-04 |
| primitive neuroectodermal tumor | 1.100 | 8.7e-04 |
| sonic hedgehog group medulloblastoma | 1.100 | 1.3e-02 |
| tuberculosis | -1.500 | 8.8e-06 |
MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAIMDSNNFLGNC 1 - 70 GVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLDIIKLAGVHTVANCFVV 71 - 140 PMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQ 141 - 210 ELGPDCILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQ 211 - 280 SLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSN 281 - 350 QIKKLSEAYNERLLHTPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVSGYTFR 351 - 420 GFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLDRCLKAVRKERSKESDDNYDKTEDVDIEEMALKLDN 421 - 490 VLLDTYQDASS 491 - 501 //
