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Tchem
GP6
Platelet glycoprotein VI

Protein Summary
Description
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310373
  • ENSP00000308782
  • ENSG00000088053
  • ENST00000333884
  • ENSP00000334552
  • ENST00000417454
  • ENSP00000394922
  • ENST00000612184
  • ENSP00000479873
  • ENSG00000277439
  • ENST00000616456
  • ENSP00000483314
  • ENST00000622279
  • ENSP00000484029

Symbol
  • GPIV
  • GPVI
  • BDPLT11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.93
cellular component
0.79
disease
0.78
cell type or tissue
0.75
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.79   (req: < 5)
Gene RIFs: 183   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.79   (req: >= 5)
Gene RIFs: 183   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3