You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GPN1
GPN-loop GTPase 1

Protein Summary
Description
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264718
  • ENSP00000264718
  • ENSG00000198522
  • ENST00000407583
  • ENSP00000384255
  • ENST00000424214
  • ENSP00000398115
  • ENST00000458167
  • ENSP00000412170
  • ENST00000503738
  • ENSP00000427269
  • ENST00000515877
  • ENSP00000424678
  • ENST00000610189
  • ENSP00000476446
  • ENST00000616939
  • ENSP00000484680

Symbol
  • MBDIN
  • RPAP4
  • XAB1
  • XAB1
  • MBDIN
  • NTPBP
  • RPAP4
  • ATPBD1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
molecular function
0.91
histone modification site profile
0.84
transcription factor perturbation
0.8
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.54   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.54   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0