Tbio GPAM Glycerol-3-phosphate acyltransferase 1, mitochondrial

Protein Summary

Description

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q9HCL2
• Q5VW51
• Q86TA3
• GPAT-1

Gene Name

• GPAM

Ensembl ID

• ENST00000348367
• ENSP00000265276
• ENSG00000119927

Symbol

• GPAT1
• KIAA1560
• GPAT
• GPAT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
histone modification site profile	0.91
virus perturbation	0.88
disease perturbation	0.79
microRNA	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.94   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 228   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.94   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0